N
Nacilla Haicheur
Researcher at French Institute of Health and Medical Research
Publications - 13
Citations - 2294
Nacilla Haicheur is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 7, co-authored 13 publications receiving 1555 citations.
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Journal ArticleDOI
International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study
Franck Pagès,Bernhard Mlecnik,Florence Marliot,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Fang Shu Ou,Carlo Bifulco,Alessandro Lugli,Inti Zlobec,Tilman T. Rau,Martin D. Berger,Iris D. Nagtegaal,Elisa Vink-Börger,Arndt Hartmann,Carol Geppert,Julie Kolwelter,Susanne Merkel,Robert Grützmann,Marc Van den Eynde,Anne Jouret-Mourin,Alex Kartheuser,Daniel Léonard,Christophe Remue,Julia Y. Wang,Julia Y. Wang,Prashant Bavi,Michael H.A. Roehrl,Michael H.A. Roehrl,Michael H.A. Roehrl,Pamela S. Ohashi,Linh T. Nguyen,Seong Jun Han,Heather L. MacGregor,Sara Hafezi-Bakhtiari,Bradly G. Wouters,Giuseppe Masucci,Emilia Andersson,Eva Zavadova,Michal Vocka,Jan Spacek,Lubos Petruzelka,Bohuslav Konopasek,Pavel Dundr,Helena Skalova,Kristyna Nemejcova,Gerardo Botti,Fabiana Tatangelo,Paolo Delrio,Gennaro Ciliberto,Michele Maio,Luigi Laghi,Fabio Grizzi,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Bénédicte Buttard,Bénédicte Buttard,Bénédicte Buttard,Mihaela Angelova,Mihaela Angelova,Mihaela Angelova,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Pauline Maby,Pauline Maby,Pauline Maby,Sarah E. Church,Helen K. Angell,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Daniela Bruni,Daniela Bruni,Daniela Bruni,Carine El Sissy,Nacilla Haicheur,Amos Kirilovsky,Anne Berger,Christine Lagorce,Jeffrey P. Meyers,Christopher Paustian,Zipei Feng,Carmen Ballesteros-Merino,Jeroen R. Dijkstra,Carlijn van de Water,Shannon van Vliet,Nikki Knijn,Ana Maria Mușină,Dragos Viorel Scripcariu,Boryana Popivanova,Mingli Xu,Tomonobu Fujita,Shoichi Hazama,Nobuaki Suzuki,Hiroaki Nagano,Kiyotaka Okuno,Toshihiko Torigoe,Noriyuki Sato,Tomohisa Furuhata,Ichiro Takemasa,Kyogo Itoh,P. Patel,Hemangini H. Vora,Birva Shah,Jayendrakumar B. Patel,Kruti N. Rajvik,Shashank J. Pandya,Shilin N. Shukla,Yili Wang,Guanjun Zhang,Yutaka Kawakami,Francesco M. Marincola,Paolo A. Ascierto,Daniel J. Sargent,Bernard A. Fox,Bernard A. Fox,Jérôme Galon,Jérôme Galon,Jérôme Galon +120 more
TL;DR: The immunoscore provides a reliable estimate of the risk of recurrence in patients with colon cancer and supports the implementation of the consensus Immunoscore as a new component of a TNM-Immune classification of cancer.
Journal ArticleDOI
Prognostic and Predictive Values of the Immunoscore in Patients with Rectal Cancer
Maria-Gabriela Anitei,Guy Zeitoun,Bernhard Mlecnik,Florence Marliot,Nacilla Haicheur,Ana-Maria Todosi,Amos Kirilovsky,Christine Lagorce,Gabriela Bindea,Dan Ferariu,Mihai Danciu,Patrick Bruneval,Viorel Scripcariu,Jean-Marc Chevallier,Franck Zinzindohoué,Anne Berger,Jérôme Galon,Franck Pagès +17 more
TL;DR: The Immunoscore could be a useful prognostic marker in patients with rectal cancer treated by primary surgery and the determination of the immune infiltrate in biopsies before treatment could beA valuable information for the prediction of response to pCRT.
Journal ArticleDOI
Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival.
Bernhard Mlecnik,Marc Van den Eynde,Gabriela Bindea,Gabriela Bindea,Gabriela Bindea,Sarah E. Church,Sarah E. Church,Sarah E. Church,Angela Vasaturo,Angela Vasaturo,Angela Vasaturo,Tessa Fredriksen,Tessa Fredriksen,Tessa Fredriksen,Lucie Lafontaine,Lucie Lafontaine,Lucie Lafontaine,Nacilla Haicheur,Florence Marliot,Daphné Debetancourt,Géraldine Pairet,Anne Jouret-Mourin,Jean-François Gigot,Catherine Hubert,Etienne Danse,Cristina Dragean,Javier Carrasco,Yves Humblet,Viia Valge-Archer,Anne Berger,Franck Pagès,Jean-Pascal Machiels,Jérôme Galon,Jérôme Galon,Jérôme Galon +34 more
TL;DR: Responses to treatment and prolonged survival of metastatic CRC patients were statistically significantly associated with high-immune densities quantified into the least immune-infiltrated metastases, which remained the only statistically significant prognostic factor associated with DFS and OS in multivariable analysis.
Journal ArticleDOI
The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.
Marc Van den Eynde,Bernhard Mlecnik,Gabriela Bindea,Tessa Fredriksen,Sarah E. Church,Lucie Lafontaine,Nacilla Haicheur,Florence Marliot,Mihaela Angelova,Angela Vasaturo,Daniela Bruni,Anne Jouret-Mourin,Pamela Baldin,Nicolas Huyghe,Karin Haustermans,Annelies Debucquoy,Eric Van Cutsem,Jean-François Gigot,Catherine Hubert,Alex Kartheuser,Christophe Remue,Daniel Léonard,Viia Valge-Archer,Franck Pagès,Jean-Pascal Machiels,Jérôme Galon +25 more
TL;DR: The immune phenotype of the least-infiltrated metastasis had a stronger association with patient outcome than other metastases and the predictive accuracy of the Immunoscore from a single biopsy was superior to the one of programmed cell death ligand 1 (PD-L1).
Journal ArticleDOI
Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients
TL;DR: In colorectal cancer, a prognostic score ('Immunoscore') is developed that takes into account the distribution of the density of both CD3(+) lymphocytes and CD8(+) cytotoxic T cells in the tumor core and the invasive margin that could outperform TNM staging.