A
Alex Veith
Researcher at Baylor College of Medicine
Publications - 5
Citations - 199
Alex Veith is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Lung injury & Hyperoxia. The author has an hindex of 4, co-authored 5 publications receiving 110 citations.
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Journal ArticleDOI
Role of cytochrome p450s in the generation and metabolism of reactive oxygen species.
Alex Veith,Bhagavatula Moorthy +1 more
TL;DR: Specific examples whereby ROS generated by CYPs contribute to or protect against various phenomena, such as hyperoxic lung injury, oxidative hepatic toxicity, formation of DNA adducts from lipid peroxidation products are discussed.
Journal ArticleDOI
Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.
Krithika Lingappan,Suman Maity,Weiwu Jiang,Lihua Wang,Xanthi I. Couroucli,Alex Veith,Guodong Zhou,Cristian Coarfa,Bhagavatula Moorthy +8 more
TL;DR: Genotype specific differences in the transcriptome and proteome of acute hyperoxia-exposed animals are characterized using the omics platforms: microarray and Reverse Phase Proteomic Array to provide novel insights into mechanisms behind the differences in susceptibility of Cyp1a1−/− and Cyp1 a2−/ − mice to HLI and suggest novel pathways that need to be investigated as possible therapeutic targets for acute lung injury.
Journal ArticleDOI
Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type.
Alex Veith,Boura'a Bou Aram,Weiwu Jiang,Lihua Wang,Guodong Zhou,Colin R. Jefcoate,Xanthi I. Couroucli,Krithika Lingappan,Bhagavatula Moorthy +8 more
TL;DR: The hypothesis that Cyp1b1-/- mice display decreased hyperoxic lung injury than wild type counterparts is supported and that CYP1B1 may act as a pro-oxidant during hyperoxia exposure, contributing to increases in oxidative DNA damage and accumulation of lipid hydroperoxides.
Journal ArticleDOI
Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury.
Daniela Dinu,Chun Chu,Alex Veith,Krithika Lingappan,Xanthi I. Couroucli,Colin R. Jefcoate,Nader Sheibani,Bhagavatula Moorthy +7 more
TL;DR: The hypothesis that CYP1B1 plays a mechanistic role in pulmonary oxygen toxicity, and CYP 1B1-mediated apoptosis could be one of the mechanisms of oxygen toxicity is supported.