Role of cytochrome p450s in the generation and metabolism of reactive oxygen species.
Alex Veith,Bhagavatula Moorthy +1 more
TLDR
Specific examples whereby ROS generated by CYPs contribute to or protect against various phenomena, such as hyperoxic lung injury, oxidative hepatic toxicity, formation of DNA adducts from lipid peroxidation products are discussed.About:
This article is published in Current Opinion in Toxicology.The article was published on 2018-02-01 and is currently open access. It has received 148 citations till now. The article focuses on the topics: Lung injury & Cytochrome P450.read more
Citations
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Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis.
Yilong Zou,Haoxin Li,Haoxin Li,Emily T. Graham,Amy Deik,John K. Eaton,Wenyu Wang,Gerardo Sandoval-Gomez,Clary B. Clish,John G. Doench,Stuart L. Schreiber,Stuart L. Schreiber +11 more
TL;DR: Cytochrome P450 oxidoreductase is identified as a contributor to ferroptotic cell death by promoting phospholipid peroxidation in various cellular lineages and is suggested as a potential druggable target for developing antiferroptosis therapeutics.
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Functions of ROS in Macrophages and Antimicrobial Immunity
Marc Herb,Michael Schramm +1 more
TL;DR: A brief introduction to ROS and their sources in macrophages is given, the versatile roles of ROS in direct and indirect antimicrobial immune defense are summarized, and an overview of commonly used ROS probes, scavengers and inhibitors are provided.
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Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver.
Erika Ramos-Tovar,Pablo Muriel +1 more
TL;DR: In this paper, the authors link the activation of the NF-κB and NLRP3 signaling pathways via reactive oxygen species (ROS) and thioredoxin-interacting protein, respectively, linking the molecular mechanisms of oxidative stress, inflammation and fibrosis.
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The Ah Receptor: Adaptive Metabolism, Ligand Diversity, and the Xenokine Model.
TL;DR: The historical underpinnings of the current state of knowledge about AHR signal transduction are provided, a few areas of needed research are identified, and concepts such as adaptive metabolism, ligand structural diversity, and the importance of proligands in receptor activation are developed.
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The relationships between cytochromes P450 and H 2 O 2: Production, reaction, and inhibition
TL;DR: H2O2-dependent inhibition of human P450s has been studied in the laboratory, demonstrating heme destruction and also the inactivating oxidation of the heme-thiolate ligand to a sulfenic acid (-SOH).
References
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The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
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Instability and decay of the primary structure of DNA
TL;DR: The spontaneous decay of DNA is likely to be a major factor in mutagenesis, carcinogenesis and ageing, and also sets limits for the recovery of DNA fragments from fossils.
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ROS Function in Redox Signaling and Oxidative Stress
TL;DR: It is argued that redox biology, rather than oxidative stress, underlies physiological and pathological conditions.
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The Carbon Monoxide-binding Pigment of Liver Microsomes II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis
TL;DR: The pathways that regulate ROS homeostasis are crucial for mitigating the toxicity of ROS and provide strong evidence about specificity in ROS signalling.
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