B
Bhagavatula Moorthy
Researcher at Baylor College of Medicine
Publications - 137
Citations - 3515
Bhagavatula Moorthy is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Hyperoxia & Lung injury. The author has an hindex of 30, co-authored 121 publications receiving 2861 citations. Previous affiliations of Bhagavatula Moorthy include National Institutes of Health & Indian Institute of Science.
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Journal ArticleDOI
Polycyclic aromatic hydrocarbons: from metabolism to lung cancer.
TL;DR: The goal of this review is to provide a current state-of-the-science of the mechanisms of human lung carcinogenesis mediated by PAHs, the experimental approaches used to study this complex class of compounds, and future directions for research of these compounds.
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Role of cytochrome p450s in the generation and metabolism of reactive oxygen species.
Alex Veith,Bhagavatula Moorthy +1 more
TL;DR: Specific examples whereby ROS generated by CYPs contribute to or protect against various phenomena, such as hyperoxic lung injury, oxidative hepatic toxicity, formation of DNA adducts from lipid peroxidation products are discussed.
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Determination of oxidative stress in vitiligo by measuring superoxide dismutase and catalase levels in vitiliginous and non-vitiliginous skin.
P V Sravani,N. Kishore Babu,K V T Gopal,G Raghu Rama Rao,Athota Rama Rao,Bhagavatula Moorthy,T Raghava Rao +6 more
TL;DR: There is increased oxidative stress in vitiligo as is indicated by high levels of SOD and low levels of CAT in the skin of vitiliginous patients.
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Polycyclic aromatic hydrocarbon‐inducible DNA adducts: Evidence by 32P‐postlabeling and use of knockout mice for Ah receptor‐independent mechanisms of metabolic activation in vivo
Sudha R. Kondraganti,Pedro M. Fernández-Salguero,Frank J. Gonzalez,Kenneth S. Ramos,Weiwu Jiang,Bhagavatula Moorthy +5 more
TL;DR: The existence of AHR‐ and CYP1A1‐independent mechanisms of PAH metabolic activation in mouse liver is demonstrated, a phenomenon that may have important implications for PAH‐mediated carcinogenesis.
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Sex-specific differences in neonatal hyperoxic lung injury.
TL;DR: The hypothesis that male neonatal mice will be more susceptible to hyperoxic lung injury and will display larger arrest in lung alveolarization is tested and the hypothesis that sex plays a crucial role in hyperoxia-mediated lung injury in this model is supported.