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Alexei A. Aravin
Researcher at California Institute of Technology
Publications - 102
Citations - 25351
Alexei A. Aravin is an academic researcher from California Institute of Technology. The author has contributed to research in topics: Piwi-interacting RNA & Argonaute. The author has an hindex of 43, co-authored 90 publications receiving 22956 citations. Previous affiliations of Alexei A. Aravin include Watson School of Biological Sciences & Moscow State University.
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A mammalian microRNA expression atlas based on small RNA library sequencing.
Pablo Landgraf,Mirabela Rusu,Robert L. Sheridan,Alain Sewer,Alain Sewer,Nicola Iovino,Alexei A. Aravin,Sébastien Pfeffer,Amanda J. Rice,Alice O. Kamphorst,Markus Landthaler,Carolina Lin,Nicholas D. Socci,Leandro C. Hermida,Valerio Fulci,Sabina Chiaretti,Robin Foà,Julia Schliwka,Uta Fuchs,Astrid Novosel,Roman-Ulrich Müller,Roman-Ulrich Müller,Bernhard Schermer,Ute Bissels,Jason M. Inman,Quang Phan,Minchen Chien,David B. Weir,Ruchi Choksi,Gabriella De Vita,Daniela Frezzetti,Hans Ingo Trompeter,Veit Hornung,Grace Teng,Gunther Hartmann,Miklós Palkovits,Roberto Di Lauro,Peter Wernet,Giuseppe Macino,Charles E. Rogler,James W. Nagle,Jingyue Ju,F. Nina Papavasiliou,Thomas Benzing,Peter Lichter,Wayne Tam,Michael J. Brownstein,Andreas Bosio,Arndt Borkhardt,James J. Russo,Chris Sander,Mihaela Zavolan,Mihaela Zavolan,Thomas Tuschl +53 more
TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.
Journal ArticleDOI
Human MicroRNA Targets
Bino John,Anton J. Enright,Anton J. Enright,Alexei A. Aravin,Thomas Tuschl,Chris Sander,Debora S. Marks +6 more
TL;DR: This work has predicted target sites on the 3′ untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments and suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of allhuman genes.
Journal ArticleDOI
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Julius Brennecke,Alexei A. Aravin,Alexander Stark,Monica Dus,Manolis Kellis,Ravi Sachidanandam,Gregory J. Hannon +6 more
TL;DR: Examination of piwi-interacting RNAs associated with each Drosophila Piwi protein finds that Piwi and Aubergine bind RNAs that are predominantly antisense to transposons, whereas Ago3 complexes contain predominantly sense piRNAs.
Journal ArticleDOI
A novel class of small RNAs bind to MILI protein in mouse testes
Alexei A. Aravin,Dimos Gaidatzis,Sébastien Pfeffer,Sébastien Pfeffer,Sébastien Pfeffer,Mariana Lagos-Quintana,Pablo Landgraf,Nicola Iovino,Patricia L. Morris,Michael J. Brownstein,Satomi Kuramochi-Miyagawa,Toru Nakano,Minchen Chien,James J. Russo,Jingyue Ju,Robert L. Sheridan,Chris Sander,Mihaela Zavolan,Thomas Tuschl +18 more
TL;DR: A new class of small RNAs that bind to MILI in mouse male germ cells, where they accumulate at the onset of meiosis are described, and are referred to as ‘Piwi-interacting RNAs’ or piRNAs.
Journal ArticleDOI
PIWI-interacting small RNAs: the vanguard of genome defence.
TL;DR: Owing to their limited expression in gonads and their sequence diversity, piRNAs have been the most mysterious class of small non-coding RNAs regulating RNA silencing, but much progress is being made into the understanding of their biogenesis and molecular functions, including the specific subcellular compartmentalization of the piRNA pathway in granular cytoplasmic bodies.