B
Bino John
Researcher at University of Pittsburgh
Publications - 26
Citations - 11158
Bino John is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 18, co-authored 25 publications receiving 10188 citations. Previous affiliations of Bino John include Rockefeller University & State University of New York System.
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Journal ArticleDOI
Human MicroRNA Targets
Bino John,Anton J. Enright,Anton J. Enright,Alexei A. Aravin,Thomas Tuschl,Chris Sander,Debora S. Marks +6 more
TL;DR: This work has predicted target sites on the 3′ untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments and suggests that miRNA genes, which are about 1% of all human genes, regulate protein production for 10% or more of allhuman genes.
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MicroRNA targets in Drosophila
TL;DR: The results reaffirm the thesis that miRNAs have an important role in establishing the complex spatial and temporal patterns of gene activity necessary for the orderly progression of development and suggest additional roles in the function of the mature organism.
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Identification of Virus-Encoded MicroRNAs
Sébastien Pfeffer,Mihaela Zavolan,Friedrich A. Grässer,Minchen Chien,James J. Russo,Jingyue Ju,Bino John,Anton J. Enright,Debora S. Marks,Chris Sander,Thomas Tuschl +10 more
TL;DR: The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.
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Tools for comparative protein structure modeling and analysis
Narayanan Eswar,Bino John,Nebojsa Mirkovic,Andras Fiser,Valentin A. Ilyin,Ursula Pieper,Ashley C. Stuart,Marc A. Marti-Renom,Mallur S. Madhusudhan,Bozidar Yerkovich,Andrej Sali +10 more
TL;DR: The following resources for comparative protein structure modeling and analysis are described (http://salilab.org): MODELLER, a program for comparative modeling by satisfaction of spatial restraints, and MODWEB, a web server for automated comparative modeling that relies on PSI-BLAST, IMPALA and ModeLLER.
Journal ArticleDOI
Comprehensive Polyadenylation Site Maps in Yeast and Human Reveal Pervasive Alternative Polyadenylation
Fatih Ozsolak,Philipp Kapranov,Sylvain Foissac,Sang Woo Kim,Elane Fishilevich,A. Paula Monaghan,Bino John,Patrice M. Milos +7 more
TL;DR: The correlation level between sense and antisense transcripts to depend on gene expression levels, supporting the view that overlapping transcription from opposite strands may play a regulatory role and the data provide a comprehensive view of the polyadenylation state and overlapping transcription.