B
Bill R. Brinkley
Researcher at Baylor College of Medicine
Publications - 48
Citations - 6222
Bill R. Brinkley is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Mitosis & Microtubule. The author has an hindex of 33, co-authored 48 publications receiving 6037 citations.
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Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation.
Michael J. Hendzel,Y Wei,Michael A. Mancini,A. Van Hooser,Tamara A. Ranalli,Bill R. Brinkley,David P. Bazett-Jones,C D Allis +7 more
TL;DR: It is proposed that the singular phosphorylation of the amino-terminus of histone H3 may be involved in facilitating two key functions during mitosis: (1) regulate protein-protein interactions to promote binding of trans-acting factors that “drive” chromatin condensation as cells enter M-phase and (2) coordinate chromatin decondensation associated with M- phase.
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Tumour amplified kinase STK15 / BTAK induces centrosome amplification, aneuploidy and transformation
Hong Yi Zhou,Jian Kuang,Ling Zhong,Wen Lin Kuo,Joe W. Gray,Aysegul A. Sahin,Bill R. Brinkley,Subrata Sen +7 more
TL;DR: It is reported that STK15 (also known as BTAK and aurora2), encoding a centrosome-associated kinase, is amplified and overexpressed in multiple human tumour cell types, and is involved in the induction of centrosomes duplication-distribution abnormalities and aneuploidy in mammalian cells.
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Managing the centrosome numbers game: from chaos to stability in cancer cell division
TL;DR: Current data support coalescence as a mechanism for regulating the number of functional centrosomes in tumor cells and either selective inactivation of the extraCentrosomes or their coalescence into two functional spindle poles corrects the problem of centrosome excess.
Journal Article
Variations in Cell Form and Cytoskeleton in Human Breast Carcinoma Cells in Vitro
TL;DR: In human breast carcinoma cells in vitro, it is not possible to associate any specific cell morphology or cytoskeletal phenotype with cancer or metastasis in vivo, whether or not these same conclusions hold for breast tumor cells in situ remains to be determined.