D
David P. Bazett-Jones
Researcher at University of Calgary
Publications - 129
Citations - 11950
David P. Bazett-Jones is an academic researcher from University of Calgary. The author has contributed to research in topics: Chromatin & Medicine. The author has an hindex of 51, co-authored 107 publications receiving 11402 citations. Previous affiliations of David P. Bazett-Jones include University of Toronto & Scripps Health.
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Journal ArticleDOI
Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation.
Michael J. Hendzel,Y Wei,Michael A. Mancini,A. Van Hooser,Tamara A. Ranalli,Bill R. Brinkley,David P. Bazett-Jones,C D Allis +7 more
TL;DR: It is proposed that the singular phosphorylation of the amino-terminus of histone H3 may be involved in facilitating two key functions during mitosis: (1) regulate protein-protein interactions to promote binding of trans-acting factors that “drive” chromatin condensation as cells enter M-phase and (2) coordinate chromatin decondensation associated with M- phase.
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Copy number variation and selection during reprogramming to pluripotency
Samer M.I. Hussein,Nizar N. Batada,Sanna Vuoristo,Reagan W. Ching,Reija Autio,Reija Autio,Elisa Närvä,Siemon Ng,Michel Sourour,Riikka H. Hämäläinen,Cia Olsson,Karolina Lundin,Milla Mikkola,Ras Trokovic,Michael Peitz,Oliver Brüstle,David P. Bazett-Jones,Kari Alitalo,Riitta Lahesmaa,Andras Nagy,Timo Otonkoski +20 more
TL;DR: It is shown that significantly more CNVs are present in early-passage human iPS cells than intermediate passage human i PS cells, fibroblast cell origins and with human embryonic stem (ES) cells.
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Global Transcription in Pluripotent Embryonic Stem Cells
Sol Efroni,Radharani Duttagupta,Jill Cheng,Hesam Dehghani,Daniel J. Hoeppner,Chandravanu Dash,David P. Bazett-Jones,Stuart F.J. Le Grice,Ronald D.G. McKay,Kenneth H. Buetow,Thomas R. Gingeras,Tom Misteli,Eran Meshorer +12 more
TL;DR: It is proposed that global transcription is a hallmark of pluripotent ESCs, contributing to their plasticity, and that lineage specification is driven by reduction of the transcribed portion of the genome.
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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
Michael J. Kruhlak,Arkady Celeste,Graham Dellaire,Oscar Fernandez-Capetillo,Waltraud G. Müller,James G. McNally,David P. Bazett-Jones,André Nussenzweig +7 more
TL;DR: It is proposed that localized adenosine triphosphate–dependent decondensation of chromatin at DSBs establishes an accessible subnuclear environment that facilitates DNA damage signaling and repair.
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PML nuclear bodies: dynamic sensors of DNA damage and cellular stress.
TL;DR: It is proposed that PML NBs are dynamic sensors of cellular stress, which rapidly disassemble following DNA damage into large supramolecular complexes, dispersing associated repair factors to sites of damage.