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Brian C. Thomas
Researcher at University of California, Berkeley
Publications - 115
Citations - 17231
Brian C. Thomas is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Metagenomics & Genome. The author has an hindex of 60, co-authored 113 publications receiving 13967 citations. Previous affiliations of Brian C. Thomas include University of California & Planetary Science Institute.
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Journal ArticleDOI
A new view of the tree of life
Laura A. Hug,Laura A. Hug,Brett J. Baker,Karthik Anantharaman,Christopher T. Brown,Alexander J. Probst,Cindy J. Castelle,Cristina N. Butterfield,Alex W Hernsdorf,Yuki Amano,Kotaro Ise,Yohey Suzuki,Natasha Dudek,David A. Relman,David A. Relman,Kari M. Finstad,Ronald Amundson,Brian C. Thomas,Jillian F. Banfield,Jillian F. Banfield +19 more
TL;DR: New genomic data from over 1,000 uncultivated and little known organisms, together with published sequences, are used to infer a dramatically expanded version of the tree of life, with Bacteria, Archaea and Eukarya included.
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Unusual biology across a group comprising more than 15% of domain Bacteria
Christopher T. Brown,Laura A. Hug,Brian C. Thomas,Itai Sharon,Cindy J. Castelle,Andrea Singh,Michael J. Wilkins,Kelly C. Wrighton,Kenneth H. Williams,Jillian F. Banfield +9 more
TL;DR: This work reconstructed 8 complete and 789 draft genomes from bacteria representing >35 phyla and documented features that consistently distinguish these organisms from other bacteria, infer that this group, which may comprise >15% of the bacterial domain, has shared evolutionary history, and describe it as the candidate phyla radiation (CPR).
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Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system
Karthik Anantharaman,Christopher T. Brown,Laura A. Hug,Itai Sharon,Cindy J. Castelle,Alexander J. Probst,Brian C. Thomas,Andrea Singh,Michael J. Wilkins,Ulas Karaoz,Eoin L. Brodie,Kenneth H. Williams,Susan S. Hubbard,Jillian F. Banfield,Jillian F. Banfield +14 more
TL;DR: Terabase-scale cultivation-independent metagenomics is applied to aquifer sediments and groundwater and 2,540 draft-quality, near-complete and complete strain-resolved genomes are reconstructed, finding that few organisms within the community can conduct multiple sequential redox transformations.
Journal ArticleDOI
Recovery of genomes from metagenomes via a dereplication, aggregation and scoring strategy.
Christian M. K. Sieber,Christian M. K. Sieber,Alexander J. Probst,Allison Sharrar,Brian C. Thomas,Matthias Hess,Susannah G. Tringe,Jillian F. Banfield +7 more
TL;DR: A tool that enables a flexible set of existing binning algorithms to be combined, resulting in improved binning accuracy and the recovery of more near-complete genomes from metagenomes compared to standalone methods is presented.
Journal ArticleDOI
Fermentation, hydrogen, and sulfur metabolism in multiple uncultivated bacterial phyla.
Kelly C. Wrighton,Brian C. Thomas,Itai Sharon,Christopher S. Miller,Cindy J. Castelle,Nathan C Verberkmoes,Michael J. Wilkins,Robert L. Hettich,Mary S. Lipton,Kenneth H. Williams,Philip E. Long,Jillian F. Banfield,Jillian F. Banfield +12 more
TL;DR: This article uncovered metabolic characteristics for members of these phyla, and a new lineage, PER, via cultivation-independent recovery of 49 partial to near-complete genomes from an acetate-amended aquifer.