B
Brian T. Do
Researcher at Massachusetts Institute of Technology
Publications - 25
Citations - 3091
Brian T. Do is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 11, co-authored 20 publications receiving 1734 citations. Previous affiliations of Brian T. Do include University of California, Berkeley & Harvard University.
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Journal ArticleDOI
Opportunities and obstacles for deep learning in biology and medicine.
Travers Ching,Daniel Himmelstein,Brett K. Beaulieu-Jones,Alexandr A. Kalinin,Brian T. Do,Gregory P. Way,Enrico Ferrero,Paul-Michael Agapow,Michael Zietz,Michael M. Hoffman,Michael M. Hoffman,Wei Xie,Gail L. Rosen,Benjamin J. Lengerich,Johnny Israeli,Jack Lanchantin,Stephen Woloszynek,Anne E. Carpenter,Avanti Shrikumar,Jinbo Xu,Evan M. Cofer,Evan M. Cofer,Christopher A. Lavender,Srinivas C. Turaga,Amr Alexandari,Zhiyong Lu,David J. Harris,Dave DeCaprio,Yanjun Qi,Anshul Kundaje,Yifan Peng,Laura K. Wiley,Marwin H. S. Segler,Simina M. Boca,S. Joshua Swamidass,Austin Huang,Anthony Gitter,Anthony Gitter,Casey S. Greene +38 more
TL;DR: It is found that deep learning has yet to revolutionize biomedicine or definitively resolve any of the most pressing challenges in the field, but promising advances have been made on the prior state of the art.
Journal ArticleDOI
Cell-programmed nutrient partitioning in the tumour microenvironment
Bradley I. Reinfeld,Bradley I. Reinfeld,Matthew Z. Madden,Matthew Z. Madden,Melissa M. Wolf,Melissa M. Wolf,Anna Chytil,Jackie E. Bader,Andrew R. Patterson,Ayaka Sugiura,Ayaka Sugiura,Allison S. Cohen,Allison S. Cohen,Ahmed Ali,Ahmed Ali,Brian T. Do,Brian T. Do,Alexander Muir,Caroline A. Lewis,Rachel Hongo,Kirsten Young,Rachel E. Brown,Rachel E. Brown,Vera M. Todd,Vera M. Todd,Tessa Huffstater,Abin Abraham,Richard T. O’Neil,Richard T. O’Neil,Matthew H. Wilson,Matthew H. Wilson,Fuxue Xin,Fuxue Xin,M. Noor Tantawy,M. Noor Tantawy,W. David Merryman,Rachelle W. Johnson,Christopher S. Williams,Christopher S. Williams,Emily F. Mason,Frank M. Mason,Katherine E. Beckermann,Matthew G. Vander Heiden,Matthew G. Vander Heiden,H. Charles Manning,H. Charles Manning,Jeffrey C. Rathmell,Jeffrey C. Rathmell,W. Kimryn Rathmell,W. Kimryn Rathmell +49 more
TL;DR: In this article, the authors used positron emission tomography (PET) tracers to measure the access to and uptake of glucose and glutamine by specific cell subsets in the TME.
Posted ContentDOI
Cell Programmed Nutrient Partitioning in the Tumor Microenvironment
Bradley I. Reinfeld,Bradley I. Reinfeld,Matthew Z. Madden,Matthew Z. Madden,Melissa M. Wolf,Melissa M. Wolf,Anna Chytil,Jackie E. Bader,AR Patterson,Allison S. Cohen,Ahmed Ali,Ahmed Ali,Brian T. Do,Brian T. Do,Alexander Muir,Caroline A. Lewis,Rachel Hongo,Kirsten Young,Rachel E. Brown,Rachel E. Brown,Vera M. Todd,Vera M. Todd,Tessa Huffstater,Abin Abraham,Abin Abraham,Richard T. O’Neil,Richard T. O’Neil,Matthew H. Wilson,Matthew H. Wilson,F Xin,Mohammed N. Tantawy,Merryman Wd,Rachelle W. Johnson,Christopher S. Williams,Christopher S. Williams,Christopher S. Williams,Emily F. Mason,Frank M. Mason,Katy Beckermann,M. G. Vander Heiden,M. G. Vander Heiden,HC Manning,Jeffrey C. Rathmell,Wendy Kimryn Rathmell +43 more
TL;DR: Cell selective partitioning of glucose and glutamine can be exploited to develop therapies and imaging strategies to alter the metabolic programs of specific cell populations in the TME, and it is observed that intrinsic cellular programs can play a major role in the use of some nutrients.
Journal ArticleDOI
irCLIP platform for efficient characterization of protein–RNA interactions
Brian J. Zarnegar,Ryan A. Flynn,Ying Shen,Brian T. Do,Howard Y. Chang,Paul A. Khavari,Paul A. Khavari +6 more
TL;DR: A UV-C crosslinking and immunoprecipitation platform, irCLIP, is introduced, which provides an ultraefficient, fast, and nonisotopic method for the detection of protein–RNA interactions using far less material than standard protocols.
Journal ArticleDOI
Increased demand for NAD+ relative to ATP drives aerobic glycolysis
Alba Luengo,Zhaoqi Li,Dan Y. Gui,Lucas B. Sullivan,Lucas B. Sullivan,Maria Zagorulya,Brian T. Do,Raphael Ferreira,Adi Naamati,Ahmed Ali,Caroline A. Lewis,Craig J. Thomas,Stefani Spranger,Nicholas J Matheson,Nicholas J Matheson,Matthew G. Vander Heiden,Matthew G. Vander Heiden +16 more
TL;DR: In this article, the authors examined the metabolic consequence of activating the pyruvate dehydrogenase complex (PDH) to increase metabolic oxidation at the expense of fermentation and found that increasing PDH activity impairs cell proliferation by reducing the NAD+/NADH ratio.