S
Srinivas C. Turaga
Researcher at Howard Hughes Medical Institute
Publications - 52
Citations - 6295
Srinivas C. Turaga is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Segmentation & Deep learning. The author has an hindex of 21, co-authored 49 publications receiving 4822 citations. Previous affiliations of Srinivas C. Turaga include Center of Advanced European Studies and Research & Massachusetts Institute of Technology.
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Journal ArticleDOI
Opportunities and obstacles for deep learning in biology and medicine.
Travers Ching,Daniel Himmelstein,Brett K. Beaulieu-Jones,Alexandr A. Kalinin,Brian T. Do,Gregory P. Way,Enrico Ferrero,Paul-Michael Agapow,Michael Zietz,Michael M. Hoffman,Michael M. Hoffman,Wei Xie,Gail L. Rosen,Benjamin J. Lengerich,Johnny Israeli,Jack Lanchantin,Stephen Woloszynek,Anne E. Carpenter,Avanti Shrikumar,Jinbo Xu,Evan M. Cofer,Evan M. Cofer,Christopher A. Lavender,Srinivas C. Turaga,Amr Alexandari,Zhiyong Lu,David J. Harris,Dave DeCaprio,Yanjun Qi,Anshul Kundaje,Yifan Peng,Laura K. Wiley,Marwin H. S. Segler,Simina M. Boca,S. Joshua Swamidass,Austin Huang,Anthony Gitter,Anthony Gitter,Casey S. Greene +38 more
TL;DR: It is found that deep learning has yet to revolutionize biomedicine or definitively resolve any of the most pressing challenges in the field, but promising advances have been made on the prior state of the art.
Journal ArticleDOI
Connectomic reconstruction of the inner plexiform layer in the mouse retina
Moritz Helmstaedter,Kevin L. Briggman,Srinivas C. Turaga,Srinivas C. Turaga,Viren Jain,Viren Jain,H. Sebastian Seung,Winfried Denk +7 more
TL;DR: Circuit motifs that emerge from the data indicate a functional mechanism for a known cellular response in a ganglion cell that detects localized motion, and predict that another ganglions cell is motion sensitive.
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Space–time wiring specificity supports direction selectivity in the retina
J. S. Kim,Matthew J. Greene,Aleksandar Zlateski,Kisuk Lee,Mark A. Richardson,Srinivas C. Turaga,Michael J. Purcaro,Matthew Balkam,Amy Robinson,Bardia Fallah Behabadi,Michael Campos,Winfried Denk,H. Sebastian Seung,EyeWirers +13 more
TL;DR: A mathematical model shows how such ‘space–time wiring specificity’ could endow SAC dendrites with receptive fields that are oriented in space–time and therefore respond selectively to stimuli that move in the outward direction from the soma.
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Convolutional networks can learn to generate affinity graphs for image segmentation
Srinivas C. Turaga,Joseph F. Murray,Viren Jain,Fabian Roth,Moritz Helmstaedter,Kevin L. Briggman,Winfried Denk,H. Sebastian Seung +7 more
TL;DR: This work presents a machine learning approach to computing an affinity graph using a convolutional network (CN) trained using ground truth provided by human experts and shows that the CN affinity graph can be paired with any standard partitioning algorithm and improves segmentation accuracy significantly compared to standard hand-designed affinity functions.
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In Toto Imaging and Reconstruction of Post-Implantation Mouse Development at the Single-Cell Level
Katie McDole,Léo Guignard,Fernando Amat,Andrew B. Berger,Grégoire Malandain,Loic Royer,Srinivas C. Turaga,Kristin Branson,Philipp J. Keller +8 more
TL;DR: A light-sheet microscope is developed that adapts itself to the dramatic changes in size, shape, and optical properties of the post-implantation mouse embryo and captures its development from gastrulation to early organogenesis at the cellular level.