Matthew S. Shive

TL;DR: Solidification of a chitosan-glycerol phosphate/blood implant in microfracture defects improved cartilage repair compared with microfractionure alone by increasing the amount of tissue and improving its biochemical composition and cellular organization.

TL;DR: Different differences between microfracture and drilling for acute subchondral bone structure and osteocyte necrosis are revealed, and additional ongoing studies suggest these differences significantly affect long‐term cartilage repair outcome.

TL;DR: BST-CarGel treatment resulted in greater lesion filling and superior repair tissue quality compared with microfracture treatment alone, and clinical benefit was equivalent between groups at twelve months, and safety was similar.

TL;DR: BST-CarGel® was shown to be an effective mid-term cartilage repair treatment and resulted in sustained and significantly superior repair tissue quantity and quality over microfracture alone at 5 years.

TL;DR: It is concluded that the depth of bone marrow stimulation can exert important influences on cartilage repair outcomes.