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Carolyn Farrell
Researcher at Roswell Park Cancer Institute
Publications - 12
Citations - 1153
Carolyn Farrell is an academic researcher from Roswell Park Cancer Institute. The author has contributed to research in topics: Gene mutation & MLH1. The author has an hindex of 8, co-authored 12 publications receiving 1121 citations.
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Journal ArticleDOI
Genetic/familial high-risk assessment: breast and ovarian.
Mary B. Daly,Jennifer E. Axilbund,Saundra S. Buys,Beth Crawford,Carolyn Farrell,Susan Friedman,Judy Garber,Salil Goorha,Stephen B. Gruber,Heather Hampel,Virginia Kaklamani,Wendy Kohlmann,Allison W. Kurian,Jennifer K. Litton,P. Kelly Marcom,Robert L. Nussbaum,Kenneth Offit,Tuya Pal,Boris Pasche,Robert Pilarski,Gwen Reiser,Kristen M. Shannon,Jeffrey R. Smith,Elizabeth M. Swisher,Jeffrey N. Weitzel +24 more
TL;DR: Overview All cancers develop as a result of mutations in certain genes, such as those involved in the regulation of cell growth and/or DNA repair, but not all of these mutations are inherited from a parent.
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Genetic Cancer Risk Assessment and Counseling: Recommendations of the National Society of Genetic Counselors
Angela Trepanier,Mary Ahrens,Wendy McKinnon,June A. Peters,Jill Stopfer,Sherry C. Grumet,Susan Manley,Julie O. Culver,Ronald T. Acton,Joy Larsen-Haidle,Lori Ann Correia,Robin L. Bennett,Barbara Pettersen,Terri Diamond Ferlita,Josephine Wagner Costalas,Katherine Hunt,Susan Donlon,Cécile Skrzynia,Carolyn Farrell,Faith Callif-Daley,Catherine Walsh Vockley +20 more
TL;DR: These cancer genetic counseling recommendations describe the medical, psychosocial, and ethical ramifications of identifying at-risk individuals through cancer risk assessment with or without genetic testing.
Journal Article
Genomic DNA-based hMSH2 and hMLH1 mutation screening in 32 Eastern United States hereditary nonpolyposis colorectal cancer pedigrees.
Thomas K. Weber,Wendy Conlon,Nicholas J. Petrelli,Miguel A. Rodriguez-Bigas,Bernadette Keitz,James E. Pazik,Carolyn Farrell,Linda O'Malley,Maximillian Oshalim,May Abdo,Garth R. Anderson,Daniel L. Stoler,David W. Yandell +12 more
TL;DR: The results provide a clarification of the contribution of hMSH2 and hMLH1 to the HNPCC phenotype and suggest that in the majority of Eastern United States H NPCC kindreds selected by phenotype alone, the molecular genetic basis for the disease remains unknown.
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Health, Life, and Disability Insurance and Hereditary Nonpolyposis Colorectal Cancer
Miguel A. Rodriguez-Bigas,Hans F. A. Vasen,Linda O'Malley,Mary-Jo T. Rosenblatt,Carolyn Farrell,Thomas K. Weber,Nicholas J. Petrelli +6 more
TL;DR: The insurance-industry attitude regarding the offering of health, life, and disability insurance to HNPCC gene carriers and at-risk family members and access to DNA test results is assessed.
Journal ArticleDOI
Locus heterogeneity, anticipation and reduction of the chromosome 2p minimal candidate region in autosomal dominant familial spastic paraplegia.
William K. Scott,P. C. Gaskell,Felicia Lennon,Chantelle M. Wolpert,M. M. Menold,Arthur S. Aylsworth,C. Warner,Carolyn Farrell,Rose-Mary Boustany,S.G. Albright,E. Boyd,Helen Kingston,W.J.K. Cumming,Jeffery M. Vance,Margaret A. Pericak-Vance +14 more
TL;DR: Age of onset (AO) was highly variable, indicating that subtypes of SPG are more appropriately defined on a genetic basis than by AO, and no evidence for a fourth as yet unidentified SPG locus is found.