C
Christine L. Hammond
Researcher at University of Rochester
Publications - 21
Citations - 2230
Christine L. Hammond is an academic researcher from University of Rochester. The author has contributed to research in topics: Glutathione & Intracellular. The author has an hindex of 12, co-authored 20 publications receiving 1985 citations.
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Journal ArticleDOI
Glutathione dysregulation and the etiology and progression of human diseases.
Nazzareno Ballatori,Suzanne M. Krance,Sylvia Notenboom,Shujie Shi,Kim Tieu,Christine L. Hammond +5 more
TL;DR: The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases and suggests the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment.
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Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology.
TL;DR: The evidence that Mrps contribute to the regulation of cellular GSH levels and the thiol-redox state, and thus to the many biochemical processes that are influenced by this tripeptide is summarized.
Journal ArticleDOI
Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
Nazzareno Ballatori,Christine L. Hammond,Jennifer B. Cunningham,Suzanne M. Krance,Rosemarie Marchan +4 more
TL;DR: Because transport is a key step in GSH homeostasis and is intimately linked to its biological functions, GSH export proteins are likely to modulate essential cellular functions.
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Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes
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Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
TL;DR: Findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver.