Kim Tieu

TL;DR: It is suggested that Parkin, together with PINK1, modulates mitochondrial trafficking, especially to the perinuclear region, a subcellular area associated with autophagy, which may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease.

TL;DR: It is shown that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP.

TL;DR: The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases and suggests the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment.

TL;DR: Observations indicate that adenosine mediates the effects of acupuncture and that interfering withAdenosine metabolism may prolong the clinical benefit of acupuncture.

TL;DR: It is demonstrated that targeting COX-2 does not protect against MPTP-induced dopaminergic neurodegeneration by mitigating inflammation, and evidence is provided that COx-2 inhibition prevents the formation of the oxidant species dopamine-quinone, which has been implicated in the pathogenesis of PD.