S
Sylvia Notenboom
Researcher at Radboud University Nijmegen Medical Centre
Publications - 12
Citations - 1180
Sylvia Notenboom is an academic researcher from Radboud University Nijmegen Medical Centre. The author has contributed to research in topics: Multidrug resistance-associated protein 2 & Organic anion transporter 1. The author has an hindex of 9, co-authored 11 publications receiving 1059 citations. Previous affiliations of Sylvia Notenboom include Mount Desert Island Biological Laboratory & University of Minnesota.
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Journal ArticleDOI
Glutathione dysregulation and the etiology and progression of human diseases.
Nazzareno Ballatori,Suzanne M. Krance,Sylvia Notenboom,Shujie Shi,Kim Tieu,Christine L. Hammond +5 more
TL;DR: The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases and suggests the high GSH content makes cancer cells chemoresistant, which is a major factor that limits drug treatment.
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Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats.
Rosalinde Masereeuw,Sylvia Notenboom,Pascal H. E. Smeets,Alfons C. Wouterse,Frans G. M. Russel +4 more
TL;DR: The authors conclude that the renal clearance of the Mrp2 substrates calcein and fluo-3 is significantly reduced in TR(-) rat; for LY, the absence of the transporter may be compensated for by (an)other organic anion transporter(s).
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Role of NO in endothelin-regulated drug transport in the renal proximal tubule
Sylvia Notenboom,David S. Miller,David S. Miller,Paul Smits,Frans G. M. Russel,Rosalinde Masereeuw +5 more
TL;DR: The data show that NO generation follows ET binding to the basolateral ET(B) receptor and that, in activating the ET-signaling pathway, nephrotoxicants produce NO, a molecule that could contribute to subsequent toxic effects.
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Role of multidrug resistance protein 2 (MRP2) in glutathione-bimane efflux from Caco-2 and rat renal proximal tubule cells.
Sylvie A. Terlouw,Rosalinde Masereeuw,Petra H.H. van den Broek,Sylvia Notenboom,Frans G. M. Russel +4 more
TL;DR: It is concluded that in freshly isolated rat PTC glutathione conjugate excretion is mediated by other organic anion transporters rather than by Mrp2.
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Involvement of guanylyl cyclase and cGMP in the regulation of Mrp2-mediated transport in the proximal tubule.
Sylvia Notenboom,David S. Miller,David S. Miller,Paul Smits,Frans G. M. Russel,Rosalinde Masereeuw +5 more
TL;DR: Data indicate that ET regulation of Mrp2 involves activation of guanylyl cyclase and generation of cGMP, which follows NO release and precedes PKC activation.