D
Damian G. Deavall
Researcher at AstraZeneca
Publications - 4
Citations - 548
Damian G. Deavall is an academic researcher from AstraZeneca. The author has contributed to research in topics: Risk assessment & Oxidative stress. The author has an hindex of 2, co-authored 4 publications receiving 468 citations.
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Journal ArticleDOI
Drug-induced oxidative stress and toxicity.
TL;DR: The nature of ROS-induced damage on key cellular targets of oxidative stress is examined and evidence implicating ROS in clinically relevant, drug-related side effects including doxorubicin-induced cardiac damage, azidothymidine-induced myopathy, and cisplatin-induced ototoxicity is reviewed.
Journal ArticleDOI
The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator
Claire Grant,Lorna Ewart,Daniel Muthas,Damian G. Deavall,Simon A. Smith,Glen Clack,Pete Newham +6 more
TL;DR: The emetic nature of AZD3514 was predicted across a range of pre-clinical models, and the approach presented provides a valuable framework for predicition of clinical nausea and vomiting.