Ruth A. Roberts

TL;DR: It is clearly demonstrate that the major sulphated glycosaminoglycan of mouse marrow stroma, heparan sulphate4, possesses the ability to adsorb both GM-CSF and the multilineage haemopoietic growth factor, Interleukin 3 (IL-3).

TL;DR: An in-depth analysis of the state of the science on several topics critical to evaluating the relationship between the MOA for PPARα agonists and the human relevance of related animal tumors produces a range of outcomes, depending partly on the quality and quantity of MOA data available from laboratory animals and related information from human data sources.

TL;DR: The nature of ROS-induced damage on key cellular targets of oxidative stress is examined and evidence implicating ROS in clinically relevant, drug-related side effects including doxorubicin-induced cardiac damage, azidothymidine-induced myopathy, and cisplatin-induced ototoxicity is reviewed.

TL;DR: The data presented in this symposium illustrate to the toxicologist the central role played by Kupffer cells in mediating hepatotoxicity.

TL;DR: In this article, a mechanistic link between oxidative stress and elevated levels of 3,4-dihydroxyphenylacetaldehyde, a neurotoxin endogenous to dopamine neurons, was found.