Drug-induced oxidative stress and toxicity.
TLDR
The nature of ROS-induced damage on key cellular targets of oxidative stress is examined and evidence implicating ROS in clinically relevant, drug-related side effects including doxorubicin-induced cardiac damage, azidothymidine-induced myopathy, and cisplatin-induced ototoxicity is reviewed.Abstract:
Reactive oxygen species (ROS) are a byproduct of normal metabolism and have roles in cell signaling and homeostasis. Species include oxygen radicals and reactive nonradicals. Mechanisms exist that regulate cellular levels of ROS, as their reactive nature may otherwise cause damage to key cellular components including DNA, protein, and lipid. When the cellular antioxidant capacity is exceeded, oxidative stress can result. Pleiotropic deleterious effects of oxidative stress are observed in numerous disease states and are also implicated in a variety of drug-induced toxicities. In this paper, we examine the nature of ROS-induced damage on key cellular targets of oxidative stress. We also review evidence implicating ROS in clinically relevant, drug-related side effects including doxorubicin-induced cardiac damage, azidothymidine-induced myopathy, and cisplatin-induced ototoxicity.read more
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Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Asima Bhattacharyya,Asima Bhattacharyya,Asima Bhattacharyya,Ranajoy Chattopadhyay,Ranajoy Chattopadhyay,Ranajoy Chattopadhyay,Sankar Mitra,Sheila E. Crowe,Sheila E. Crowe,Sheila E. Crowe +9 more
TL;DR: Unraveling the signaling events initiated at the cellular level by oxidative free radicals as well as the physiological responses to such stress is important to better understand disease pathogenesis and to develop new therapies to manage a variety of conditions for which current therapies are not always sufficient.
Journal ArticleDOI
Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
Paul W. Burridge,Yong Fuga Li,Elena Matsa,Haodi Wu,Sang-Ging Ong,Arun Sharma,Alexandra Holmström,Alex C.Y. Chang,Michael Coronado,Antje D. Ebert,Joshua W. Knowles,Melinda L. Telli,Ronald M. Witteles,Helen M. Blau,Daniel Bernstein,Russ B. Altman,Joseph C. Wu +16 more
TL;DR: It is demonstrated that patient-specific human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) can recapitulate the predilection to doxorubicin-induced cardiotoxicity of individual patients at the cellular level.
Journal ArticleDOI
3D tumor spheroids: an overview on the tools and techniques used for their analysis.
Elisabete C. Costa,André F. Moreira,Duarte de Melo-Diogo,Vítor M. Gaspar,Marco António Paulo de Carvalho,Ilídio J. Correia +5 more
TL;DR: The present review provides an overview of the techniques that can be employed to characterize and evaluate the efficacy of anticancer therapeutics in 3D tumor spheroids.
Journal ArticleDOI
3D tumor spheroids as in vitro models to mimic in vivo human solid tumors resistance to therapeutic drugs.
Ana S. Nunes,Andreia S. Barros,Elisabete C. Costa,André F. Moreira,Ilídio J. Correia,Ilídio J. Correia +5 more
TL;DR: In this review, an overview of the drug resistance mechanisms observed in 3D tumor spheroids is provided, and examples of the therapeutic approaches that have been developed to surpass theDrug resistance mechanisms exhibited by sp heroids are described.
Journal ArticleDOI
Lipid droplet functions beyond energy storage.
Michael A. Welte,Alex P. Gould +1 more
TL;DR: Roles of lipid droplets in protein handling encompass functions in the maturation, storage, and turnover of cellular and viral polypeptides, highlighting that lipid Droplets are very adaptable organelles, performing different functions in different biological contexts.
References
More filters
Journal ArticleDOI
Pharmacological interventions for somatoform disorders in adults.
Maria Kleinstäuber,Michael Witthöft,Andrés Steffanowski,Harm W.J. van Marwijk,Wolfgang Hiller,Michael J. Lambert +5 more
TL;DR: A systematic review and meta-analysis of placebo-controlled studies examined the efficacy and tolerability of different types of antidepressants, the combination of an antidepressant and an antipsychotic, antipsychotics alone, or natural products in adults with somatoform disorders in adults to improve optimal treatment decisions.
Journal ArticleDOI
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery
Sandeep Robert Datta,Henryk Dudek,Xu Tao,Shane C. Masters,Haian Fu,Yukiko Gotoh,Michael E. Greenberg +6 more
TL;DR: It is shown that growth factor activation of the PI3'K/Akt signaling pathway culminates in the phosphorylation of the BCL-2 family member BAD, thereby suppressing apoptosis and promoting cell survival.
Journal ArticleDOI
Cellular survival: a play in three Akts
TL;DR: The mechanisms by which survival factors regulate the PI3K/c-Akt cascade, the evidence that activation of the PI 3K/ c-AKT pathway promotes cell survival, and the current spectrum of c- akt targets and their roles in mediating c- Akt-dependent cell survival are reviewed.