D
Dean E. Morbeck
Researcher at Mayo Clinic
Publications - 53
Citations - 1947
Dean E. Morbeck is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Embryo culture & Pregnancy. The author has an hindex of 18, co-authored 48 publications receiving 1658 citations. Previous affiliations of Dean E. Morbeck include University of Rochester.
Papers
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Journal ArticleDOI
Fat tissue, aging, and cellular senescence
Tamara Tchkonia,Dean E. Morbeck,Thomas von Zglinicki,Jan M. van Deursen,Joseph Lustgarten,Heidi Scrable,Sundeep Khosla,Michael D. Jensen,James L. Kirkland +8 more
TL;DR: A hypothetical model in which cellular stress and preadipocyte overutilization with aging induce cellular senescence, leading to impaired adipogenesis, failure to sequester lipotoxic fatty acids, inflammatory cytokine and chemokine generation, and innate and adaptive immune response activation is proposed.
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Composition of commercial media used for human embryo culture
Dean E. Morbeck,Rebecca L. Krisher,Jason R. Herrick,Nikola A. Baumann,Dietrich Matern,Thomas P. Moyer +5 more
TL;DR: Culture media composition varies widely, with differences in pyruvate, lactate, and amino acids especially notable, and Blastocyst development was culture media dependent and showed an interaction with oxygen concentration and presence of protein.
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Type of culture media does not affect embryo kinetics: a time-lapse analysis of sibling oocytes
TL;DR: The absence of differences in morphokinetics between two different media concepts validates the algorithm for embryo selection in diverse culture conditions.
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Cdc20 is critical for meiosis I and fertility of female mice.
Fang Jin,Masakazu Hamada,Liviu Malureanu,Karthik B. Jeganathan,Wei Zhou,Dean E. Morbeck,Jan M. van Deursen +6 more
TL;DR: It is demonstrated that the physiologically effective threshold level of Cdc20 is high for female meiosis I and identified CDC20 hypomorphism as a mechanism for chromosome missegregation and formation of aneuploid gametes.
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Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome
Barbara Luke,Morton B. Brown,Dean E. Morbeck,Susan B. A. Hudson,Charles C. Coddington,Judy E. Stern +5 more
TL;DR: Ovarian hyperstimulation syndrome is associated with a higher likelihood of pregnancy, and multiple gestations, but also greater risks for adverse pregnancy outcomes.