Heidi Scrable

TL;DR: A hypothetical model in which cellular stress and preadipocyte overutilization with aging induce cellular senescence, leading to impaired adipogenesis, failure to sequester lipotoxic fatty acids, inflammatory cytokine and chemokine generation, and innate and adaptive immune response activation is proposed.

TL;DR: Overexpression of the short isoform of p53 (p44) has unexpectedly uncovered a role for p53 in the regulation of size and life span in the mouse, suggesting pathways of gene activity known to regulate longevity in lower organisms are linked in mammals via p53 to mechanisms for controlling cell proliferation.

TL;DR: In this article, the authors identified 13 residues in SIRT1 that are phosphorylated in vivo using mass spectrometry and found that phosphorylation by phosphatases in vitro resulted in decreased NAD+-dependent deacetylase activity.

TL;DR: It is found that SIRT1 decreased with age in tissues in which mitotic activity also declines, such as the thymus and testis, but not in tissuessuch as the brain in which there is little change inMitotic activity throughout life.

TL;DR: The observations that capacitation alters the protein composition of the detergent-resistant membrane fractions is consistent with the hypothesis that cholesterol efflux during capacitation dissociates lipid raft constituents, initiating signaling events that lead to sperm capacitation.