Objective: The aim was to update the guidelines for the management of thyroid dysfunction during pregnancy and postpartum published previously in 2007. A summary of changes between the 2007 and 2012 version is identified in the Supplemental Data (published on The Endocrine Society's Journals Online web site at http://jcem.endojournals.org). Evidence: This evidence-based guideline was developed according to the U.S. Preventive Service Task Force, grading items level A, B, C, D, or I, on the basis of the strength of evidence and magnitude of net benefit (benefits minus harms) as well as the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence. Consensus Process: The guideline was developed through a series of e-mails, conference calls, and one face-to-face meeting. An initial draft was prepared by the Task Force, with the help of a medical writer, and reviewed and commented on by members of The Endocri...

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Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline

The preterm parturition syndrome

ACOG practice bulletin: Clinical management guidelines for obstetrician-gynecologists

Inflammation has been implicated in the mechanisms responsible for preterm and term parturition, as well as fetal injury. Out of all of the suspected causes of preterm labour and delivery, infection and/or inflammation is the only pathological process for which both a firm causal link with preterm birth has been established and a molecular pathophysiology defined. Inflammation has also been implicated in the mechanism of spontaneous parturition at term. Most cases of histopathological inflammation and histological chorioamnionitis, both in preterm and term labour, are sub-clinical in nature. The isolation of bacteria in the amniotic fluid, known as microbial invasion of the amniotic cavity, is a pathological finding; the frequency of which is dependent upon the clinical presentation and gestational age. There is a window of time during which it may be possible to detect a 'molecular signature of inflammation' by analysis of the transcriptome before histological evidence is observed. This article reviews the role of inflammation in preterm and term parturition. It is possible that modulation of inflammation using anti-inflammatory cytokines, corticoids, antioxidants and/or other factors may complement antibiotic therapy and limit fetal injury.

Inflammation in preterm and term labour and delivery.

Objective: The objective is to provide clinical guidelines for the management of thyroid problems present during pregnancy and in the postpartum. Participants: The Chair was selected by the Clinical Guidelines Subcommittee (CGS) of The Endocrine Society. The Chair requested participation by the Latin American Thyroid Society, the Asia and Oceania Thyroid Society, the American Thyroid Association, the European Thyroid Association, and the American Association of Clinical Endocrinologists, and each organization appointed a member to the task force. Two members of The Endocrine Society were also asked to participate. The group worked on the guidelines for 2 yr and held two meetings. There was no corporate funding, and no members received remuneration. Evidence: Applicable published and peer-reviewed literature of the last two decades was reviewed, with a concentration on original investigations. The grading of evidence was done using the United States Preventive Services Task Force system and, where possible, the GRADE system. Consensus Process: Consensus was achieved through conference calls, two group meetings, and exchange of many drafts by E-mail. The manuscript was reviewed concurrently by the Society’s CGS, Clinical Affairs Committee, members of The Endocrine Society, and members of each of the collaborating societies. Many valuable suggestions were received and incorporated into the final document. Each of the societies endorsed the guidelines. Conclusions: Management of thyroid diseases during pregnancy requires special considerations because pregnancy induces major changes in thyroid function, and maternal thyroid disease can have adverse effects on the pregnancy and the fetus. Care requires coordination among several healthcare professionals. Avoiding maternal (and fetal) hypothyroidism is of major importance because of potential damage to fetal neural development, an increased incidence of miscarriage, and preterm delivery. Maternal hyperthyroidism and its treatment may be accompanied by coincident problems in fetal thyroid function. Autoimmune thyroid disease is associated with both increased rates of miscarriage, for which the appropriate medical response is uncertain at this time, and postpartum thyroiditis. Fine-needle aspiration cytology should be performed for dominant thyroid nodules discovered in pregnancy. Radioactive isotopes must be avoided during pregnancy and lactation. Universal screening of pregnant women for thyroid disease is not yet supported by adequate studies, but case finding targeted to specific groups of patients who are at increased risk is strongly supported. (J Clin Endocrinol Metab 92: S1–S47, 2007)

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Clinical practice guideline: Management of thyroid dysfunction during pregnancy and postpartum: An endocrine society clinical practice guideline

Congenital diaphragmatic hernia. Epidemiology and outcome

Sound levels in the human uterus.

A LARGE goiter in a fetus is a rare yet potentially dangerous condition. A large goiter may cause hyperextension of the neck of the fetus, resulting in malpresentation and complicating labor and delivery.1 In the neonate, the goiter can obstruct the trachea and thus cause asphyxia and death.2 , 3 In this case report, we describe the diagnosis of a large goiter in a fetus, the use of percutaneous umbilical-blood sampling to establish the diagnosis of fetal hypothyroidism, and the successful treatment of the goiter and hypothyroidism by the injection of thyroxine into the amniotic fluid. Case Report A 30-year-old woman with . . .

Successful in utero treatment of fetal goiter and hypothyroidism.

Accuracy of ultrasound for the prediction of placenta accreta.

Systems of quantifying and scoring cervical factors have been sought for years to predict the duration of labor and to determine which patients may successfully and safely undergo induction of labor. Early methods of cervical assessment generally attempted to classify patients as having favorable or unfavorable cervices based on dichotomous variables. Since then, obstetricians have begun to appreciate the usefulness of having a single score derived from the degree of ripeness of several cervical characteristics. The scoring system that has become most prevalent is the Bishop score. This system and its modifications take into account the dilation, effacement, consistency, and position of the cervix in addition to the station of the presenting part. Many have evaluated and confirmed the validity of the Bishop score. Among the factors considered in assigning the score, the strongest association with successful labor seems to be with cervical dilation. The Bishop score has been criticized for not attributing more significance to cervical dilation. However, despite this criticism, none of the modifications to the original scoring system have been shown to improve predictability. More recently, the use of ultrasound assessment of the cervix has been suggested to improve prediction of the success of labor induction. However, convincing evidence that this technique provides significant additional information when compared to digital examination is lacking. The Bishop score would seem to be the best and most cost-effective method currently available to assess the cervix and predict the likelihood of success of labor induction and the duration of such an induction.

Douglas S. Richards

Papers

Congenital diaphragmatic hernia. Epidemiology and outcome

Sound levels in the human uterus.

Successful in utero treatment of fetal goiter and hypothyroidism.

Accuracy of ultrasound for the prediction of placenta accreta.

Preinduction cervical assessment.