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Evelyne Vanneste
Researcher at Katholieke Universiteit Leuven
Publications - 22
Citations - 2133
Evelyne Vanneste is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Chromosome instability & Aneuploidy. The author has an hindex of 15, co-authored 22 publications receiving 1958 citations. Previous affiliations of Evelyne Vanneste include The Catholic University of America & Catholic University of Leuven.
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Chromosome instability is common in human cleavage-stage embryos
Evelyne Vanneste,Thierry Voet,Cédric Le Caignec,Cédric Le Caignec,Michèle Ampe,Peter Konings,Cindy Melotte,Sophie Debrock,Mustapha Amyere,Miikka Vikkula,Frans Schuit,Jean-Pierre Fryns,Geert Verbeke,Thomas D'Hooghe,Yves Moreau,Joris Vermeesch +15 more
TL;DR: In this article, a new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells, which revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles.
Journal Article
Chromosome instability is common in human cleavage stage embryos
Evelyne Vanneste,Thierry Voet,Michèle Ampe,Peter Konings,Cindy Melotte,Jean-Pierre Fryns,Geert Verbeke,Thomas D'Hooghe,Yves Moreau,Joris Vermeesch +9 more
TL;DR: This study establishes that chromosome instability is also common during early human embryogenesis and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders.
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Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos
Afroditi Mertzanidou,Leeanda Wilton,Jiqiu Cheng,Claudia Spits,Evelyne Vanneste,Yves Moreau,Joris Vermeesch,Karen Sermon +7 more
TL;DR: Finding such a high rate of aneuploidy and mosaicism in excellent quality embryos from cycles with a high implantation rate warrants further research on the origin and significance of chromosomal abnormalities in human preimplantation embryos.
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Chromosome Instability Is Common in Human Cleavage-Stage Embryos
Journal ArticleDOI
Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial
Sophie Debrock,Cindy Melotte,Carl Spiessens,Karen Peeraer,Evelyne Vanneste,L Meeuwis,Christel Meuleman,Jean-Pierre Frijns,Joris Vermeesch,Thomas D'Hooghe +9 more
TL;DR: The hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS was not confirmed.