T
Thierry Voet
Researcher at Katholieke Universiteit Leuven
Publications - 139
Citations - 13605
Thierry Voet is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Stem cell & Genome. The author has an hindex of 46, co-authored 126 publications receiving 10360 citations. Previous affiliations of Thierry Voet include University of Texas MD Anderson Cancer Center & Wellcome Trust Sanger Institute.
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Journal ArticleDOI
Identification of the tumour transition states occurring during EMT
Ievgenia Pastushenko,Audrey Brisebarre,Alejandro Sifrim,Alejandro Sifrim,Marco Fioramonti,Tatiana Revenco,Soufiane Boumahdi,Alexandra Van Keymeulen,Daniel Brown,Virginie Moers,Sophie Lemaire,Sarah De Clercq,Esmeralda Minguijón,Cédric Balsat,Youri Sokolow,Christine Dubois,Florian De Cock,Samuel Scozzaro,Federico Sopena,Angel Lanas,Nicky D'Haene,Isabelle Salmon,Jean-Christophe Marine,Thierry Voet,Thierry Voet,Panagiota A. Sotiropoulou,Cédric Blanpain +26 more
TL;DR: A large panel of cell surface markers in skin and mammary primary tumours is screened, and the existence of multiple tumour subpopulations associated with different EMT stages are identified: from epithelial to completely mesenchymal states, passing through intermediate hybrid states.
Journal ArticleDOI
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution
Elza C de Bruin,Nicholas McGranahan,Nicholas McGranahan,Richard Mitter,Max Salm,David C. Wedge,Lucy R. Yates,Lucy R. Yates,Mariam Jamal-Hanjani,Seema Shafi,Nirupa Murugaesu,Andrew Rowan,Eva Grönroos,Madiha A. Muhammad,Stuart Horswell,Marco Gerlinger,Ignacio Varela,David T. Jones,John Marshall,Thierry Voet,Thierry Voet,Peter Van Loo,Peter Van Loo,Doris Rassl,Robert C. Rintoul,Sam M. Janes,Siow Ming Lee,Martin Forster,Tanya Ahmad,David Lawrence,Mary Falzon,Arrigo Capitanio,Timothy T. Harkins,Clarence C. Lee,Warren Tom,Enock Teefe,Shann-Ching Chen,Sharmin Begum,Adam Rabinowitz,Benjamin Phillimore,Bradley Spencer-Dene,Gordon Stamp,Zoltan Szallasi,Zoltan Szallasi,Nik Matthews,Aengus Stewart,Peter J. Campbell,Charles Swanton,Charles Swanton +48 more
TL;DR: 25 spatially distinct regions from seven operable NSCLCs were sequenced and found evidence of branched evolution, with driver mutations arising before and after subclonal diversification, and pronounced intratumor heterogeneity in copy number alterations, translocations, and mutations associated with APOBEC cytidine deaminase activity.
Journal ArticleDOI
Chromosome instability is common in human cleavage-stage embryos
Evelyne Vanneste,Thierry Voet,Cédric Le Caignec,Cédric Le Caignec,Michèle Ampe,Peter Konings,Cindy Melotte,Sophie Debrock,Mustapha Amyere,Miikka Vikkula,Frans Schuit,Jean-Pierre Fryns,Geert Verbeke,Thomas D'Hooghe,Yves Moreau,Joris Vermeesch +15 more
TL;DR: In this article, a new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells, which revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles.
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G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
Iain C. Macaulay,Wilfried Haerty,Parveen Kumar,Yang I. Li,Yang I. Li,Tim Xiaoming Hu,Mabel J Teng,Mubeen Goolam,Nathalie Saurat,Paul Coupland,Lesley Shirley,Miriam Smith,Niels Van der Aa,Ruby Banerjee,Peter D. Ellis,Michael A. Quail,Harold Swerdlow,Harold Swerdlow,Magdalena Zernicka-Goetz,Frederick J. Livesey,Chris P. Ponting,Chris P. Ponting,Thierry Voet,Thierry Voet +23 more
TL;DR: G&T-seq, a method for separating and sequencing genomic DNA and full-length mRNA from single cells, is described and cellular properties that could not be inferred from DNA or RNA sequencing alone are discovered.
Journal ArticleDOI
Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity
Christof Angermueller,Stephen J. Clark,Heather J. Lee,Heather J. Lee,Iain C. Macaulay,Mabel J Teng,Tim Xiaoming Hu,Tim Xiaoming Hu,Tim Xiaoming Hu,Felix Krueger,Sébastien A. Smallwood,Chris P. Ponting,Chris P. Ponting,Thierry Voet,Thierry Voet,Gavin Kelsey,Oliver Stegle,Wolf Reik,Wolf Reik +18 more
TL;DR: ScM&T-seq, a method for parallel single-cell genome-wide methylome and transcriptome sequencing that allows for the discovery of associations between transcriptional and epigenetic variation, revealed previously unrecognized associations between heterogeneously methylated distal regulatory elements and transcription of key pluripotency genes.