M
Michèle Ampe
Researcher at Katholieke Universiteit Leuven
Publications - 7
Citations - 1367
Michèle Ampe is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Chromosome instability & Copy-number variation. The author has an hindex of 4, co-authored 7 publications receiving 1250 citations.
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Journal ArticleDOI
Chromosome instability is common in human cleavage-stage embryos
Evelyne Vanneste,Thierry Voet,Cédric Le Caignec,Cédric Le Caignec,Michèle Ampe,Peter Konings,Cindy Melotte,Sophie Debrock,Mustapha Amyere,Miikka Vikkula,Frans Schuit,Jean-Pierre Fryns,Geert Verbeke,Thomas D'Hooghe,Yves Moreau,Joris Vermeesch +15 more
TL;DR: In this article, a new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells, which revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles.
Journal Article
Chromosome instability is common in human cleavage stage embryos
Evelyne Vanneste,Thierry Voet,Michèle Ampe,Peter Konings,Cindy Melotte,Jean-Pierre Fryns,Geert Verbeke,Thomas D'Hooghe,Yves Moreau,Joris Vermeesch +9 more
TL;DR: This study establishes that chromosome instability is also common during early human embryogenesis and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders.
Journal ArticleDOI
Chromosome Instability Is Common in Human Cleavage-Stage Embryos
Journal ArticleDOI
Microarray analysis of copy number variation in single cells
Peter Konings,Evelyne Vanneste,S Jackmaert,Michèle Ampe,Geert Verbeke,Yves Moreau,Joris Vermeesch,Thierry Voet +7 more
TL;DR: This protocol minimizes false-positive variant calling and enables uniparental isodisomy detection in single cells and provides quality assessment, allowing the exclusion of uninterpretable single-cell WGA samples.