F
Fengchun Ye
Researcher at Case Western Reserve University
Publications - 53
Citations - 2810
Fengchun Ye is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Lytic cycle & Kaposi's sarcoma-associated herpesvirus. The author has an hindex of 27, co-authored 48 publications receiving 2522 citations. Previous affiliations of Fengchun Ye include University Hospitals of Cleveland & McGill University.
Papers
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Journal ArticleDOI
Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNA.
Xiufen Lei,Zhiqiang Bai,Fengchun Ye,Jianping Xie,Chan Gil Kim,Chan Gil Kim,Yufei Huang,Yufei Huang,Shou-Jiang Gao +8 more
TL;DR: It is shown that deletion of a 14 microRNA cluster from the KSHV genome significantly enhances viral lytic replication as a result of reduced NF-κB activity.
Journal ArticleDOI
Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation
TL;DR: The cellular and molecular basis of Kaposi's sarcoma-associated herpesvirus latency and reactivation is reviewed with a focus on the most recent advancements in the field.
Journal ArticleDOI
Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency.
Fengchun Ye,Fuchun Zhou,Roble Bedolla,Tiffany Jones,Xiufen Lei,Tao Kang,Moraima Guadalupe,Shou-Jiang Gao +7 more
TL;DR: It is shown that the reactive oxygen species (ROS) hydrogen peroxide (H2O2) induces KSHV reactivation from latency through both autocrine and paracrine signaling, and indicates that antioxidants and anti-inflammation drugs could be promising preventive and therapeutic agents for effectively targeting K SHV replication and KSHv-related malignancies.
Book ChapterDOI
Molecular biology of KSHV in relation to AIDS-associated oncogenesis.
TL;DR: Although HAART significantly reduces HIV viral load, the entire T-cell repertoire and immune function may not be completely restored, and clinically significant immune deficiency is not necessary for the induction of KSHV-related malignancy.
Journal ArticleDOI
Modulation of Kaposi's Sarcoma-Associated Herpesvirus Infection and Replication by MEK/ERK, JNK, and p38 Multiple Mitogen-Activated Protein Kinase Pathways during Primary Infection
TL;DR: Results indicate that, by modulating multiple MAPK pathways, KSHV manipulates the host cells to facilitate its entry into the cells and postentry productive lytic replication during primary infection.