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Xiufen Lei
Researcher at University of Texas Health Science Center at San Antonio
Publications - 14
Citations - 911
Xiufen Lei is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Lytic cycle & Kaposi's sarcoma-associated herpesvirus. The author has an hindex of 8, co-authored 12 publications receiving 849 citations. Previous affiliations of Xiufen Lei include University of Texas at San Antonio & Greehey Children's Cancer Research Institute.
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Journal ArticleDOI
Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNA.
Xiufen Lei,Zhiqiang Bai,Fengchun Ye,Jianping Xie,Chan Gil Kim,Chan Gil Kim,Yufei Huang,Yufei Huang,Shou-Jiang Gao +8 more
TL;DR: It is shown that deletion of a 14 microRNA cluster from the KSHV genome significantly enhances viral lytic replication as a result of reduced NF-κB activity.
Journal ArticleDOI
Mechanisms of Kaposi's Sarcoma-Associated Herpesvirus Latency and Reactivation
TL;DR: The cellular and molecular basis of Kaposi's sarcoma-associated herpesvirus latency and reactivation is reviewed with a focus on the most recent advancements in the field.
Journal ArticleDOI
Reactive oxygen species hydrogen peroxide mediates Kaposi's sarcoma-associated herpesvirus reactivation from latency.
Fengchun Ye,Fuchun Zhou,Roble Bedolla,Tiffany Jones,Xiufen Lei,Tao Kang,Moraima Guadalupe,Shou-Jiang Gao +7 more
TL;DR: It is shown that the reactive oxygen species (ROS) hydrogen peroxide (H2O2) induces KSHV reactivation from latency through both autocrine and paracrine signaling, and indicates that antioxidants and anti-inflammation drugs could be promising preventive and therapeutic agents for effectively targeting K SHV replication and KSHv-related malignancies.
Journal ArticleDOI
Kaposi's Sarcoma-Associated Herpesvirus Latent Gene vFLIP Inhibits Viral Lytic Replication through NF-κB-Mediated Suppression of the AP-1 Pathway: a Novel Mechanism of Virus Control of Latency
Fengchun Ye,Fuchun Zhou,Jianping Xie,Tao Kang,Whitney Greene,Kurt Kuhne,Xiufen Lei,Qui-Hua Li,Shou-Jiang Gao +8 more
TL;DR: It is shown that the KSHV latent gene vFLIP promotes viral latency by inhibiting viral lytic replication and indicates that the effect of the NF-κB pathway on K SHV replication is determined by the status of the AP-1 pathway, providing a mechanistic explanation for the contradictory role of the NPKB pathway.
Journal ArticleDOI
KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways.
Rosalie Moody,Ying Zhu,Yufei Huang,Xiaodong Cui,Tiffany Jones,Roble Bedolla,Xiufen Lei,Zhiqiang Bai,Shou-Jiang Gao +8 more
TL;DR: These works define for the first time an essential viral determinant for KSHV-induced oncogenesis and identify NF-κB as a critical pathway targeted by the viral miRs.