F
Frederik J. van Schooten
Researcher at Maastricht University
Publications - 179
Citations - 6577
Frederik J. van Schooten is an academic researcher from Maastricht University. The author has contributed to research in topics: DNA damage & Medicine. The author has an hindex of 44, co-authored 147 publications receiving 5682 citations. Previous affiliations of Frederik J. van Schooten include Karolinska Institutet & Maastricht University Medical Centre.
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Journal ArticleDOI
Telomere length assessment: biomarker of chronic oxidative stress?
TL;DR: Since chronic oxidative stress plays a major role in the pathophysiology of several chronic inflammatory diseases, it is hypothesized that telomere length is reducing at a faster rate during oxidative stress, therefore, assessment of telomeres length might be a useful biomarker of disease progression.
Journal ArticleDOI
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
Carole L. Yauk,Aris Polyzos,Andrea Rowan-Carroll,Christopher M. Somers,Roger W. L. Godschalk,Frederik J. van Schooten,M. Lynn Berndt,Igor P. Pogribny,Igor Koturbash,Andrew M. Williams,George R. Douglas,Olga Kovalchuk +11 more
TL;DR: Sperm DNA was hypermethylated in mice breathing ambient relative to HEPA-filtered air and this change persisted following removal from the environmental exposure, and increased germ-line DNA mutation frequencies may cause population-level changes in genetic composition and disease.
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The versatile use of exhaled volatile organic compounds in human health and disease
Agnes W. Boots,Joep J B N van Berkel,Jan W. Dallinga,Agnieszka Smolinska,Emile F Wouters,Frederik J. van Schooten +5 more
TL;DR: The currently available methodologies regarding sampling, sample analysis and data processing as well as their advantages and potential drawbacks are described and different application possibilities of VOC profiling are discussed.
Journal ArticleDOI
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead
William H. Goodson,Leroy Lowe,David O. Carpenter,Michael Gilbertson,Abdul Manaf Ali,Adela Lopez de Cerain Salsamendi,Ahmed Lasfar,Amancio Carnero,Amaya Azqueta,Amedeo Amedei,Amelia K Charles,Andrew Collins,Andrew Ward,Anna C. Salzberg,Annamaria Colacci,Ann-Karin Olsen,Arthur Berg,Barry J. Barclay,Binhua P. Zhou,Carmen Blanco-Aparicio,Carolyn J. Baglole,Chenfang Dong,Chiara Mondello,Chia-Wen Hsu,Christian C. Naus,Clement G. Yedjou,Colleen S. Curran,Dale W. Laird,Daniel C. Koch,Danielle J Carlin,Dean W. Felsher,Debasish Roy,Dustin G. Brown,Edward A. Ratovitski,Elizabeth P. Ryan,Emanuela Corsini,Emilio Rojas,Eun-Yi Moon,Ezio Laconi,Fabio Marongiu,Fahd Al-Mulla,Ferdinando Chiaradonna,Firouz Darroudi,Francis Martin,Frederik J. van Schooten,Gary S. Goldberg,Gerard Wagemaker,Gladys N. Nangami,Gloria M. Calaf,Gloria M. Calaf,Graeme Williams,Gregory T. Wolf,Gudrun Koppen,Gunnar Brunborg,H. Kim Lyerly,Harini Krishnan,Hasiah Ab Hamid,Hemad Yasaei,Hideko Sone,Hiroshi Kondoh,Hosni Salem,Hsue-Yin Hsu,Hyun Ho Park,Igor Koturbash,Isabelle R. Miousse,A. Ivana Scovassi,James E. Klaunig,Jan Vondráček,Jayadev Raju,Jesse Roman,Jesse Roman,John Pierce Wise,Jonathan Whitfield,Jordan Woodrick,Joseph Christopher,Josiah Ochieng,Juan Fernando Martinez-Leal,Judith Weisz,Julia Kravchenko,Jun Sun,Kalan R. Prudhomme,Kannan Badri Narayanan,Karine A. Cohen-Solal,Kim Moorwood,Laetitia Gonzalez,Laura Soucek,Le Jian,Leandro S. D'Abronzo,Liang Tzung Lin,Lin Li,Linda S M Gulliver,Lisa J. McCawley,Lorenzo Memeo,Louis Vermeulen,Luc Leyns,Luoping Zhang,Mahara Valverde,Mahin Khatami,Maria Romano,Marion Chapellier,Marc A. Williams,Mark Wade,Masoud H. Manjili,Matilde E. Lleonart,Menghang Xia,Michael J. Gonzalez,Michalis V. Karamouzis,Micheline Kirsch-Volders,Monica Vaccari,Nancy B. Kuemmerle,Nancy B. Kuemmerle,Neetu Singh,Nichola Cruickshanks,Nicole Kleinstreuer,Nik van Larebeke,Nuzhat Ahmed,Olugbemiga Ogunkua,Periyadan K. Krishnakumar,Pankaj Vadgama,Paola A. Marignani,Paramita M. Ghosh,Patricia Ostrosky-Wegman,Patricia A. Thompson,Paul Dent,Petr Heneberg,Philippa D. Darbre,Po Sing Leung,Pratima Nangia-Makker,Qiang Shawn Cheng,R. Brooks Robey,R. Brooks Robey,Rabeah Al-Temaimi,Rabindra Roy,Rafaela Andrade-Vieira,Ranjeet Kumar Sinha,Rekha Mehta,Renza Vento,Renza Vento,Riccardo Di Fiore,Richard Ponce-Cusi,Rita Dornetshuber-Fleiss,Rita Dornetshuber-Fleiss,Rita Nahta,Robert C. Castellino,Roberta Palorini,Roslida Abd Hamid,Sabine A. S. Langie,Sakina E. Eltom,Samira A. Brooks,Sandra Ryeom,Sandra S. Wise,Sarah N Bay,Shelley A. Harris,Shelley A. Harris,Silvana Papagerakis,Simona Romano,Sofia Pavanello,Staffan Eriksson,Stefano Forte,Stephanie C. Casey,Sudjit Luanpitpong,Tae-Jin Lee,Takemi Otsuki,Tao Chen,Thierry Massfelder,Thomas Sanderson,Tiziana Guarnieri,Tove Hultman,Valérian Dormoy,Valérian Dormoy,Valerie Odero-Marah,Venkata S. Sabbisetti,Véronique Maguer-Satta,W. Kimryn Rathmell,Wilhelm Engström,William K. Decker,William H. Bisson,Yon Rojanasakul,Yunus A. Luqmani,Zhenbang Chen,Zhiwei Hu +180 more
TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.
Journal ArticleDOI
Genotoxic effects of neutrophils and hypochlorous acid.
Nejla Güngör,Ad M. Knaapen,Ad M. Knaapen,Armelle Munnia,Marco Peluso,Guido R.M.M. Haenen,Roland K. Chiu,Roger W. L. Godschalk,Frederik J. van Schooten +8 more
TL;DR: Investigation of the capacity of the major neutrophilic oxidant hypochlorous acid (HOCl), which is formed by myeloperoxidase (MPO), to induce DNA damage and mutagenicity in lung cells indicates that MPO catalysed formation of HOCl during lung inflammation should be considered as a significant source of neutrophil-induced genotoxicity.