G
Giulia Chinetti
Researcher at French Institute of Health and Medical Research
Publications - 71
Citations - 9934
Giulia Chinetti is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Receptor & Peroxisome proliferator-activated receptor. The author has an hindex of 33, co-authored 65 publications receiving 9267 citations. Previous affiliations of Giulia Chinetti include Lille University of Science and Technology & Pasteur Institute.
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Journal ArticleDOI
Activation of human aortic smooth-muscle cells is inhibited by PPARα but not by PPARγ activators
Bart Staels,Wolfgang Koenig,Aida Habib,Régine Merval,Marilyne Lebret,Inés Pineda Torra,Inés Pineda Torra,Philippe Delerive,Philippe Delerive,Abdessamad Fadel,Abdessamad Fadel,Giulia Chinetti,Giulia Chinetti,Jean-Charles Fruchart,Jean-Charles Fruchart,Jamila Najib,Jamila Najib,Jacques Maclouf,Alain Tedgui +18 more
TL;DR: It is concluded that activators of PPARα inhibit the inflammatory response of aortic smooth-muscle cells and decrease the concentration of plasma acute-phase proteins, indicating that PPAR α in the vascular wall may influence the process of atherosclerosis and re-stenosis.
Journal ArticleDOI
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.
Giulia Chinetti,Sophie Lestavel,Bocher,Alan T. Remaley,Bernadette Neve,Inés Pineda Torra,Elisabeth Teissier,A Minnich,Michael C. Jaye,Nicolas Duverger,H B Brewer,Jean-Charles Fruchart,Clavey,Bart Staels +13 more
TL;DR: A regulatory role is identified for PPAR-α andPPAR-γ in the first steps of the reverse-cholesterol-transport pathway through the activation of ABCA1-mediated cholesterol efflux in human macrophages.
Journal ArticleDOI
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.
Giulia Chinetti,S. Griglio,M. Antonucci,Inés Pineda Torra,Philippe Delerive,Zouher Majd,Jean-Charles Fruchart,John Chapman,Jamila Najib,Bart Staels +9 more
TL;DR: It is shown that the PPARα and PPARγ forms are expressed in differentiated human monocyte-derived macrophages, which participate in inflammation control and atherosclerotic plaque formation and demonstrate a novel function of PPAR in human macrophage with likely consequences in inflammation and Atherosclerosis.
Journal ArticleDOI
Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation.
TL;DR: Findings indicate a modulatory role for PPARs in the control of the inflammatory response with potential therapeutic applications in inflammation-related diseases, such as atherosclerosis and inflammatory bowel disease.
Journal ArticleDOI
Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
TL;DR: This Review will focus on the mechanisms of action of PPARα in metabolic diseases and their associated vascular pathologies.