J
Jean-Charles Fruchart
Researcher at Lille University of Science and Technology
Publications - 124
Citations - 11956
Jean-Charles Fruchart is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Nuclear receptor. The author has an hindex of 53, co-authored 124 publications receiving 11459 citations. Previous affiliations of Jean-Charles Fruchart include university of lille & Pasteur Institute of Lille.
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Journal ArticleDOI
PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway.
Giulia Chinetti,Sophie Lestavel,Bocher,Alan T. Remaley,Bernadette Neve,Inés Pineda Torra,Elisabeth Teissier,A Minnich,Michael C. Jaye,Nicolas Duverger,H B Brewer,Jean-Charles Fruchart,Clavey,Bart Staels +13 more
TL;DR: A regulatory role is identified for PPAR-α andPPAR-γ in the first steps of the reverse-cholesterol-transport pathway through the activation of ABCA1-mediated cholesterol efflux in human macrophages.
Journal ArticleDOI
Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages.
Giulia Chinetti,S. Griglio,M. Antonucci,Inés Pineda Torra,Philippe Delerive,Zouher Majd,Jean-Charles Fruchart,John Chapman,Jamila Najib,Bart Staels +9 more
TL;DR: It is shown that the PPARα and PPARγ forms are expressed in differentiated human monocyte-derived macrophages, which participate in inflammation control and atherosclerotic plaque formation and demonstrate a novel function of PPAR in human macrophage with likely consequences in inflammation and Atherosclerosis.
Journal ArticleDOI
Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation.
TL;DR: Findings indicate a modulatory role for PPARs in the control of the inflammatory response with potential therapeutic applications in inflammation-related diseases, such as atherosclerosis and inflammatory bowel disease.
Journal ArticleDOI
CLA-1/SR-BI Is Expressed in Atherosclerotic Lesion Macrophages and Regulated by Activators of Peroxisome Proliferator-Activated Receptors
Giulia Chinetti,Franck G. Gbaguidi,S. Griglio,Ziad Mallat,M. Antonucci,Philippe Poulain,John Chapman,Jean-Charles Fruchart,Alain Tedgui,Jamila Najib-Fruchart,Bart Staels +10 more
TL;DR: The data demonstrate that CLA-1/SR-BI is expressed in atherosclerotic lesion macrophages and induced by PPAR activation, identifying a potential role for PPARs in cholesterol homeostasis in atheosclerotic lesions of apoE-null mice treated with either PPARgamma or PPARalpha ligands.
Journal ArticleDOI
Pleiotropic Actions of Peroxisome Proliferator–Activated Receptors in Lipid Metabolism and Atherosclerosis
Olivier Barbier,I. Pineda Torra,Y. Duguay,Christophe Blanquart,Jean-Charles Fruchart,Corine Glineur,Bart Staels +6 more
TL;DR: Peroxisome proliferator–activated receptors modulate the onset and evolution of metabolic disorders predisposing to atherosclerosis and exert direct antiatherogenic actions at the level of the vascular wall by regulating gene transcription.