G
Giuseppina Bonizzi
Researcher at European Institute of Oncology
Publications - 43
Citations - 6245
Giuseppina Bonizzi is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 16, co-authored 27 publications receiving 5771 citations. Previous affiliations of Giuseppina Bonizzi include University of California, Berkeley & University of California, San Diego.
Papers
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Journal ArticleDOI
The two NF-κB activation pathways and their role in innate and adaptive immunity
Giuseppina Bonizzi,Michael Karin +1 more
TL;DR: Results strongly suggest that the classical and alternative pathways to NF-κB activation have distinct regulatory functions, one that is mostly involved in innate immunity and the other in adaptive immunity.
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Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
Uwe Senftleben,Yixue Cao,Gutian Xiao,Florian R. Greten,Gertraud Krähn,Giuseppina Bonizzi,Yi Chen,Yinling Hu,Abraham Fong,Shao Cong Sun,Michael Karin +10 more
TL;DR: It is shown that IKKα is required for B cell maturation, formation of secondary lymphoid organs, increased expression of certain NF-κB target genes, and processing of the NF-σκB2 (p100) precursor.
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The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
Angelo Cicalese,Giuseppina Bonizzi,Cristina Elisabetta Pasi,Mario Faretta,Simona Ronzoni,Barbara Giulini,Cathrin Brisken,Saverio Minucci,Pier Paolo Di Fiore,Pier Giuseppe Pelicci +9 more
TL;DR: It is demonstrated that p53 regulates polarity of cell division in mammary SCs and suggested that loss of p53 favors symmetric divisions of cancer SCs, contributing to tumor growth.
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IKKα Provides an Essential Link between RANK Signaling and Cyclin D1 Expression during Mammary Gland Development
Yixue Cao,Giuseppina Bonizzi,Tiffany N. Seagroves,Florian R. Greten,Randall S. Johnson,Emmett V. Schmidt,Michael Karin +6 more
TL;DR: IKKα is a critical intermediate in a pathway that controls mammary epithelial proliferation in response to RANK signaling via cyclin D1 through NF-κB activation.
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Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimers
Giuseppina Bonizzi,Magali Bebien,Dennis C. Otero,Kirsten E Johnson-Vroom,Yixue Cao,Don Vu,Anil G. Jegga,Bruce J. Aronow,Gourisankar Ghosh,Robert C. Rickert,Michael Karin +10 more
TL;DR: The basis for the IKKα dependence of the induction of these genes in response to engagement of the lymphotoxin β receptor is investigated and a novel type of NF‐κB‐binding site is identified that is preferentially recognized by RelB:p52 dimers.