G
Gregory P. Downey
Researcher at University of Colorado Denver
Publications - 255
Citations - 18389
Gregory P. Downey is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Lung injury & Phosphorylation. The author has an hindex of 73, co-authored 240 publications receiving 16504 citations. Previous affiliations of Gregory P. Downey include St. Michael's GAA, Sligo & University of Colorado Boulder.
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Journal ArticleDOI
An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals
Gustavo Matute-Bello,Gregory P. Downey,Bethany B. Moore,Steve D. Groshong,Michael A. Matthay,Arthur S. Slutsky,Wolfgang M. Kuebler +6 more
TL;DR: This list of features and measurements of ALI is intended as a guide for investigators, and ultimately investigators should choose the particular measurements that best suit the experimental questions being addressed as well as take into consideration any unique aspects of the experimental design.
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Efficacy and safety of sirolimus in lymphangioleiomyomatosis.
Francis X. McCormack,Yoshikazu Inoue,Joel Moss,Lianne G. Singer,Charlie Strange,Koh Nakata,Alan F. Barker,Jeffrey T. Chapman,Mark L. Brantly,James M. Stocks,Kevin K. Brown,Joseph P. Lynch,Hilary J. Goldberg,Lisa R. Young,Lisa R. Young,Brent W. Kinder,Gregory P. Downey,Gregory P. Downey,Eugene J. Sullivan,Thomas V. Colby,Roy T. McKay,Marsha M. Cohen,Leslie L. Korbee,Angelo M. Taveira-DaSilva,Hye-Seung Lee,Jeffrey P. Krischer,Bruce C. Trapnell,Bruce C. Trapnell +27 more
TL;DR: In patients with LAM, sirolimus stabilized lung function, reduced serum VEGF-D levels, and was associated with a reduction in symptoms and improvement in quality of life.
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Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
TL;DR: In this article, reactive oxygen (ROS) and reactive nitrogen (RNS) species have a dual function: they function as potent antimicrobial agents by virtue of their ability to kill microbial pathogens directly and participate as signaling molecules that regulate diverse physiological signaling pathways in neutrophils.
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Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries
TL;DR: Data suggest that neutrophil stiffening may be both necessary and sufficient for the retention that is observed in lung and other capillaries in the acute inflammatory process and may be the result of increased stiffness stimulated by chemoattractants.
Journal ArticleDOI
Neutrophil activation and acute lung injury.
Warren L. Lee,Gregory P. Downey +1 more
TL;DR: The inflammatory response in ALI may initially be adaptive, such as the pivotal role played by neutrophils in a bacterial or fungal infection, and it is the persistence or the dysregulation of neutrophil activation that may lead to ALI.