S
Sean Lang
Researcher at University of Toronto
Publications - 11
Citations - 682
Sean Lang is an academic researcher from University of Toronto. The author has contributed to research in topics: Platelet & Neonatal alloimmune thrombocytopenia. The author has an hindex of 10, co-authored 11 publications receiving 610 citations. Previous affiliations of Sean Lang include St. Michael's Hospital & Canadian Blood Services.
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Journal ArticleDOI
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries
Conglei Li,June Li,Yan-Yan Li,Yan-Yan Li,Sean Lang,Sean Lang,Issaka Yougbaré,Guangheng Zhu,Pingguo Chen,Pingguo Chen,Heyu Ni +10 more
TL;DR: New data suggest that platelets are important immune cells and may contribute to innate and adaptive immunity under both physiological and pathological conditions.
Journal ArticleDOI
Maternal anti-platelet β3 integrins impair angiogenesis and cause intracranial hemorrhage
Issaka Yougbaré,Sean Lang,Hong Yang,Pingguo Chen,Xu Zhao,Wei-She Tai,Darko Zdravic,Brian Vadasz,Conglei Li,Siavash Piran,Alexandra H. Marshall,Guangheng Zhu,Heidi Tiller,Mette Kjaer Killie,Shelley R. Boyd,Howard Leong-Poi,Xiao-Yan Wen,Bjørn Skogen,S. Lee Adamson,John Freedman,Heyu Ni +20 more
TL;DR: The data suggest that fetal hemostasis is distinct and that impairment of angiogenesis rather than thrombocytopenia likely causes FNAIT-associated ICH, and indicates that maternal IVIG therapy can effectively prevent this devastating disorder.
Journal ArticleDOI
The maternal immune response to fetal platelet GPIbα causes frequent miscarriage in mice that can be prevented by intravenous IgG and anti-FcRn therapies.
Conglei Li,Siavash Piran,Pingguo Chen,Pingguo Chen,Sean Lang,Sean Lang,Alessandro Zarpellon,Joseph W. Jin,Joseph W. Jin,Guangheng Zhu,Adili Reheman,Dianne E. van der Wal,Elisa K. Simpson,Ran Ni,Peter L. Gross,Jerry Ware,Zaverio M. Ruggeri,John Freedman,Heyu Ni,Heyu Ni +19 more
TL;DR: The maternal immune response to fetal GPIbα causes what is believed to be a previously unidentified, nonclassical FNIT in mice, and results suggest that a similar pathology may have masked the severity and frequency of human anti-GPIb α-mediated FNIT, but also point to possible therapeutic interventions.
Journal ArticleDOI
Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.
Hong Yang,Hong Yang,Hong Yang,Sean Lang,Zhimin Zhai,Ling Li,Walter H. A. Kahr,Pingguo Chen,Pingguo Chen,Jelena Brkic,Christopher M. Spring,Matthew J. Flick,Jay L. Degen,John Freedman,John Freedman,Heyu Ni +15 more
TL;DR: It is demonstrated that fibrinogen may play important roles in inflammation, thrombosis, and hemostasis via enhancement of platelet P-selectin expression and P- selectin as an activation marker on platelets should be used with caution.
Journal ArticleDOI
Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy
Pingguo Chen,Pingguo Chen,Conglei Li,Sean Lang,Guangheng Zhu,Adili Reheman,Christopher M. Spring,John Freedman,Heyu Ni +8 more
TL;DR: The data suggest that targeting FcRn may be a potential therapy for human FNIT as well as other maternal pathogenic antibody-mediated diseases.