H
Héctor Guadalajara
Researcher at Autonomous University of Madrid
Publications - 58
Citations - 1687
Héctor Guadalajara is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Medicine & Colorectal cancer. The author has an hindex of 18, co-authored 45 publications receiving 1251 citations. Previous affiliations of Héctor Guadalajara include Complutense University of Madrid & Hospital Universitario La Paz.
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Journal ArticleDOI
Long-term Efficacy and Safety of Stem Cell Therapy (Cx601) for Complex Perianal Fistulas in Patients With Crohn’s Disease
Julián Panés,Damián García-Olmo,Gert Van Assche,Jean-Frederic Colombel,Walter Reinisch,Walter Reinisch,Daniel C. Baumgart,Axel Dignass,Maria Nachury,Marc Ferrante,Lili Kazemi-Shirazi,Jean Charles Grimaud,Fernando de la Portilla,Eran Goldin,Marie Paule Richard,Mary Carmen Diez,Ignacio Tagarro,Anne Leselbaum,Silvio Danese,Jean Fred Colombel,Anton Stift,Jörg Tschmelitsch,Karl Mrak,Herbert Tilg,Irmgard Kroberger,André D'Hoore,Danny De Looze,Filip Baert,Paul Pattyn,Philippe Zerbib,Frank Zerbib,Stephanie Viennot,Jean-Louis Dupas,Pierre-Charles Orsoni,Xavier Hébuterne,Amine Rahili,Matthieu Allez,Yves Panis,Max Reinshagen,Roland Scherer,Andreas Sturm,Wolfgang Kruis,Daniel-Simon Duek,Matti Waterman,Adi Lahat-Zok,Oded Zmora,Hagit Tulchinsky,Y. Edden,Antonino Spinelli,Vito Annese,Imerio Angriman,Gabriele Riegler,Francesco Selvaggi,Bas Oldenburg,Lennard Gilissen,Gust Van Montfort,Mark Löwenberg,Adrianus Willem Bemelman,Raúl Almenara,María Dolores Martín Arranz,Mariano García-Arranz,Javier P. Gisbert,Rosana Palasí,Carlos Taxonera Samso,José Manuel Herrera Justiniano,Ricardo Rada,Mª Teresa Butrón,Daniel Carpio López,Antonio López-Sanromán,Joaquín Hinojosa de Val,Amparo Solana,F. Xavier González Argenté,Carlos Pastor,Héctor Guadalajara +73 more
TL;DR: In a phase 3 trial of patients with Crohn's disease and treatment-refractory complex perianal fistulas, Cx601 is found to be safe and effective in closing external openings, compared with placebo, after 1 year.
Journal ArticleDOI
Autologous expanded adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistulas: a phase III randomized clinical trial (FATT 1: fistula Advanced Therapy Trial 1) and long-term evaluation.
Maria Dolores Herreros,Mariano García-Arranz,Héctor Guadalajara,Paloma De-La-Quintana,Damián García-Olmo +4 more
TL;DR: In treatment of complex fistula-in-ano, a dose of 20 or 60 million adipose-derived stem cells alone or in combination with fibrin glue was considered a safe treatment, achieving healing rates of approximately 40% at 6 months and of more than 50% at 1-year follow-up.
Journal ArticleDOI
Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas
Héctor Guadalajara,Héctor Guadalajara,Dolores Herreros,Paloma De-La-Quintana,Jacobo Trébol,Mariano García-Arranz,Damián García-Olmo +6 more
TL;DR: A low proportion of the stem cell-treated patients with closure after the procedure remained free of recurrence after more than 3 years of follow-up, reaffirmed the very good safety profile of the treatment.
Journal ArticleDOI
Treatment of Crohn's-Related Rectovaginal Fistula With Allogeneic Expanded-Adipose Derived Stem Cells: A Phase I–IIa Clinical Trial
Mariano García-Arranz,Maria Dolores Herreros,Carolina González-Gómez,Paloma de la Quintana,Héctor Guadalajara,T. Georgiev-Hristov,Jacobo Trébol,Damián García-Olmo +7 more
TL;DR: Expanded allogeneic adipose‐derived stem‐cell injection is a safe and feasible therapy for treating Crohn’s‐related rectovaginal fistula, and the healing success rate seems promising (60%).
Journal ArticleDOI
Chromatin immunoprecipitation from fixed clinical tissues reveals tumor-specific enhancer profiles
Paloma Cejas,Lewyn Li,Nicholas K. O’Neill,Melissa Duarte,Prakash Rao,Michaela Bowden,Chensheng W. Zhou,Marta Mendiola,Emilio Burgos,Jaime Feliu,Juan Moreno-Rubio,Héctor Guadalajara,Victor Moreno,Damián García-Olmo,Joaquim Bellmunt,Stephanie A. Mullane,Michelle S. Hirsch,Christopher Sweeney,Andrea L. Richardson,X. Shirley Liu,Myles Brown,Ramesh A. Shivdasani,Henry W. Long +22 more
TL;DR: Fixed-tissue chromatin immunoprecipitation sequencing (FiT-seq) is described, a method that enables reliable extraction of soluble chromatin from formalin-fixed paraffin-embedded (FFPE) tissue samples for accurate detection of histone marks.