J
Jacobo Trébol
Researcher at University of Salamanca
Publications - 14
Citations - 559
Jacobo Trébol is an academic researcher from University of Salamanca. The author has contributed to research in topics: Stem cell & Medicine. The author has an hindex of 7, co-authored 11 publications receiving 467 citations. Previous affiliations of Jacobo Trébol include Autonomous University of Madrid & Hospital Universitario La Paz.
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Journal ArticleDOI
Long-term follow-up of patients undergoing adipose-derived adult stem cell administration to treat complex perianal fistulas
Héctor Guadalajara,Héctor Guadalajara,Dolores Herreros,Paloma De-La-Quintana,Jacobo Trébol,Mariano García-Arranz,Damián García-Olmo +6 more
TL;DR: A low proportion of the stem cell-treated patients with closure after the procedure remained free of recurrence after more than 3 years of follow-up, reaffirmed the very good safety profile of the treatment.
Journal ArticleDOI
Treatment of enterocutaneous fistula in Crohn’s Disease with adipose-derived stem cells: a comparison of protocols with and without cell expansion
Damián García-Olmo,Damián García-Olmo,Dolores Herreros,Maria Pascual,Isabel Pascual,Paloma De-La-Quintana,Jacobo Trébol,Mariano García-Arranz,Mariano García-Arranz +8 more
TL;DR: Although a comparison of case series cannot be considered firm evidence, a therapeutic protocol that uses expansion prior to implantation does seem to be more effective than one that uses SVF cells directly from a lipoaspirate sample.
Journal ArticleDOI
Treatment of Crohn's-Related Rectovaginal Fistula With Allogeneic Expanded-Adipose Derived Stem Cells: A Phase I–IIa Clinical Trial
Mariano García-Arranz,Maria Dolores Herreros,Carolina González-Gómez,Paloma de la Quintana,Héctor Guadalajara,T. Georgiev-Hristov,Jacobo Trébol,Damián García-Olmo +7 more
TL;DR: Expanded allogeneic adipose‐derived stem‐cell injection is a safe and feasible therapy for treating Crohn’s‐related rectovaginal fistula, and the healing success rate seems promising (60%).
Journal ArticleDOI
Adipose-Derived Stem Cells in Crohn's Rectovaginal Fistula
Dolores C. García-Olmo,Dolores Herreros,Paloma De-La-Quintana,Héctor Guadalajara,Jacobo Trébol,T. Georgiev-Hristov,Mariano García-Arranz +6 more
TL;DR: The conclusion of the study with Mary is that the use of mesenchymal stem cells derived from adipose tissue is secure, either in autologous or allogeneic form, which confirms the safety of using these cells in patients at least in the fistulizing Crohn's disease environment.
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Sutures enriched with adipose-derived stem cells decrease the local acute inflammation after tracheal anastomosis in a murine model
T. Georgiev-Hristov,Mariano García-Arranz,Ignacio Garcia-Gomez,Miguel Ángel García-Cabezas,Jacobo Trébol,Luz Vega-Clemente,Prudencio Díaz-Agero,Damián García-Olmo +7 more
TL;DR: Biosutures are a comfortable way of stem cell delivery to the surgical field without modification of the operative protocol and suppress the local acute inflammatory reaction in the tracheal anastomosis and cause an early switch from acute to chronic inflammation.