H
Hiroyuki Hanai
Researcher at Hamamatsu University
Publications - 13
Citations - 748
Hiroyuki Hanai is an academic researcher from Hamamatsu University. The author has contributed to research in topics: Ulcerative colitis & Colitis. The author has an hindex of 6, co-authored 13 publications receiving 723 citations.
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Journal ArticleDOI
Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytes.
Abby R. Saniabadi,Hiroyuki Hanai,Ken Takeuchi,Kazuo Umemura,Mitsuyoshi Nakashima,Taro Adachi,Chikako Shima,Ingvar Bjarnason,Robert Löfberg +8 more
TL;DR: A long lasting effect on inflammatory cytokine generation,chemokine activities or immunomodulation is likely, but the precisemechanisms involved are not fully understood yet.
Journal ArticleDOI
Leukocyte adsorptive apheresis for the treatment of active ulcerative colitis: a prospective, uncontrolled, pilot study.
Hiroyuki Hanai,Fumitoshi Watanabe,Ken Takeuchi,Takayuki Iida,Masami Yamada,Yasushi Iwaoka,Abby R. Saniabadi,Isao Matsushita,Yoshihiko Sato,Kotaro Tozawa,Hajime Arai,Takahisa Furuta,Ken Sugimoto,Ingvar Bjarnason +13 more
TL;DR: Reduction of circulating granulocyte and monocyte adsorptive apheresis results in alleviation of inflammation and promotes clinical remission in patients with severe active UC that has not responded to intensive corticosteroid treatment.
Journal ArticleDOI
Adsorptive Granulocyte and Monocyte Apheresis versus Prednisolone in Patients with Corticosteroid-Dependent Moderately Severe Ulcerative Colitis
Hiroyuki Hanai,Fumitoshi Watanabe,Masami Yamada,Yoshihiko Sato,Ken Takeuchi,Takayuki Iida,Kotaro Tozawa,Tatsuo Tanaka,Yasushi Maruyama,Isao Matsushita,Yasushi Iwaoka,Kazuto Kikuch,Abby R. Saniabadi +12 more
TL;DR: GMA appeared to be an effective adjunct to standard drug therapy of moderately severe UC by promoting remission and sparing steroids in patients with steroid-dependent UC.
Journal ArticleDOI
Relationship between fecal calprotectin, intestinal inflammation, and peripheral blood neutrophils in patients with active ulcerative colitis.
Hiroyuki Hanai,Ken Takeuchi,Takayuki Iida,Nobuhito Kashiwagi,Abby R. Saniabadi,Isao Matsushita,Yoshihiko Sato,Naoki Kasuga,Toshihiro Nakamura +8 more
TL;DR: In conclusion, GM appear to contribute to intestinal inflammation and UC activity and reduction of these cells by GMA should benefit patients with active UC, and the correlations among calprotectin, UC activities, and PB neutrophils should serve as the basis for preemptive actions to control this disease.
Journal ArticleDOI
Correlation of serum soluble TNF-alpha receptors I and II levels with disease activity in patients with ulcerative colitis.
Hiroyuki Hanai,Fumitoshi Watanabe,Masami Yamada,Yoshihiko Sato,Ken Takeuchi,Takayuki Iida,Kotaro Tozawa,Tatsuo Tanaka,Yasuhiko Maruyama,Isao Matsushita,Yasushi Iwaoka,Abby R. Saniabadi +11 more
TL;DR: The sources of s-RI/RII are believed to be activated monocytes and neutrophils with further release when these leukocytes adhere to the column carriers and should contribute to the clinical efficacy of this procedure.