K
Ken Takeuchi
Researcher at Toho University
Publications - 42
Citations - 3625
Ken Takeuchi is an academic researcher from Toho University. The author has contributed to research in topics: Ulcerative colitis & Inflammatory bowel disease. The author has an hindex of 25, co-authored 42 publications receiving 3398 citations. Previous affiliations of Ken Takeuchi include King's College London & Hamamatsu University.
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Journal ArticleDOI
Identification of an intestinal heme transporter.
M Shayeghi,Gladys O. Latunde-Dada,Jonathan S. Oakhill,Abas H. Laftah,Ken Takeuchi,Neil Halliday,Yasmin Khan,Alice Warley,Fiona E. McCann,Robert C. Hider,David M. Frazer,Gregory J. Anderson,Chris D. Vulpe,Robert J. Simpson,Andrew T. McKie +14 more
TL;DR: A membrane protein named HCP 1 (heme carrier protein 1), with homology to bacterial metal-tetracycline transporters, mediates heme uptake by cells in a temperature-dependent and saturable manner and is indicated to be the long-sought intestinal heme transporter.
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Curcumin Maintenance Therapy for Ulcerative Colitis: Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial
Hiroyuki Hanai,Takayuki Iida,Ken Takeuchi,Fumitoshi Watanabe,Yasuhiko Maruyama,Akira Andoh,Tomoyuki Tsujikawa,Yosihihide Fujiyama,Keiichi Mitsuyama,Michio Sata,Masami Yamada,Yasushi Iwaoka,Kazunari Kanke,Hideyuki Hiraishi,Kazuhisa Hirayama,Hajime Arai,Shigehito Yoshii,Masato Uchijima,Toshi Nagata,Yukio Koide +19 more
TL;DR: Curcumin seems to be a promising and safe medication for maintaining remission in patients with quiescent UC, and improved both CAI and EI, thus suppressing the morbidity associated with UC.
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Prevalence and mechanism of nonsteroidal anti-inflammatory drug-induced clinical relapse in patients with inflammatory bowel disease.
Ken Takeuchi,Simon Smale,Purushothaman Premchand,Laurence Maiden,Roy Sherwood,Bjarni Thjodleifsson,Einar Björnsson,Ingvar Bjarnason +7 more
TL;DR: NSAID ingestion is associated with frequent and early clinical relapse of quiescent inflammatory bowel disease, and the mechanism appears to be due to dual inhibition of the COX enzymes.
Journal ArticleDOI
Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytes.
Abby R. Saniabadi,Hiroyuki Hanai,Ken Takeuchi,Kazuo Umemura,Mitsuyoshi Nakashima,Taro Adachi,Chikako Shima,Ingvar Bjarnason,Robert Löfberg +8 more
TL;DR: A long lasting effect on inflammatory cytokine generation,chemokine activities or immunomodulation is likely, but the precisemechanisms involved are not fully understood yet.
Journal ArticleDOI
Leukocyte adsorptive apheresis for the treatment of active ulcerative colitis: a prospective, uncontrolled, pilot study.
Hiroyuki Hanai,Fumitoshi Watanabe,Ken Takeuchi,Takayuki Iida,Masami Yamada,Yasushi Iwaoka,Abby R. Saniabadi,Isao Matsushita,Yoshihiko Sato,Kotaro Tozawa,Hajime Arai,Takahisa Furuta,Ken Sugimoto,Ingvar Bjarnason +13 more
TL;DR: Reduction of circulating granulocyte and monocyte adsorptive apheresis results in alleviation of inflammation and promotes clinical remission in patients with severe active UC that has not responded to intensive corticosteroid treatment.