K
Kazuo Umemura
Researcher at Hamamatsu University School of Medicine
Publications - 269
Citations - 6600
Kazuo Umemura is an academic researcher from Hamamatsu University School of Medicine. The author has contributed to research in topics: Middle cerebral artery & Ischemia. The author has an hindex of 42, co-authored 257 publications receiving 6078 citations. Previous affiliations of Kazuo Umemura include Hamamatsu University.
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Journal ArticleDOI
Essential in vivo roles of the c-type lectin receptor CLEC-2: Embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets
Katsue Suzuki-Inoue,Osamu Inoue,Guo Ding,Satoshi Nishimura,Kazuya Hokamura,Koji Eto,Hirokazu Kashiwagi,Yoshiaki Tomiyama,Yutaka Yatomi,Kazuo Umemura,Yonchol Shin,Masanori Hirashima,Yukio Ozaki +12 more
TL;DR: It is proposed that CLEC-2 could be an ideal novel target protein for an anti-platelet drug, which inhibits pathological thrombus formation but not physiological hemostasis.
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Adacolumn, an adsorptive carrier based granulocyte and monocyte apheresis device for the treatment of inflammatory and refractory diseases associated with leukocytes.
Abby R. Saniabadi,Hiroyuki Hanai,Ken Takeuchi,Kazuo Umemura,Mitsuyoshi Nakashima,Taro Adachi,Chikako Shima,Ingvar Bjarnason,Robert Löfberg +8 more
TL;DR: A long lasting effect on inflammatory cytokine generation,chemokine activities or immunomodulation is likely, but the precisemechanisms involved are not fully understood yet.
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Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease
Masato Yoneda,Shuhei Naka,Kazuhiko Nakano,Koichiro Wada,Hiroki Endo,Hironori Mawatari,Kento Imajo,Ryota Nomura,Kazuya Hokamura,Masafumi Ono,Shogo Murata,Iwai Tohnai,Yoshio Sumida,Toshihide Shima,Masae Kuboniwa,Kazuo Umemura,Yoshinori Kamisaki,Atsuo Amano,Takeshi Okanoue,Takashi Ooshima,Atsushi Nakajima +20 more
TL;DR: Infection with high-virulence P. gingivalis might be an additional risk factor for the development/progression of NAFLD/NASH and non-surgical periodontal treatments carried out for 3 months ameliorated the liver function parameters, such as the serum levels of AST and ALT.
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Effects of pemirolast and tranilast on intimal thickening after arterial injury in the rat.
TL;DR: It is suggested that antiallergic agents directly inhibit migration of smooth-muscle cells to the intima from the media and proliferation in the intIMA, and that pemirolast has more potent antihyperplastic action than does tranilast.
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Pharmacokinetics of Voriconazole and Cytochrome p450 2C19 Genetic Status
TL;DR: There is a need for further development with respect to what hepatic marker or classification systems to use in pharmacokinetic hepatic impairment studies and the pharmaceutical industry is encouraged to implement its knowledge of the mechanism of drug elimination into the design of the studies.