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Irina Vetter
Researcher at University of Queensland
Publications - 208
Citations - 8806
Irina Vetter is an academic researcher from University of Queensland. The author has contributed to research in topics: Venom & Conotoxin. The author has an hindex of 42, co-authored 178 publications receiving 6691 citations. Previous affiliations of Irina Vetter include Academy of Sciences of the Czech Republic.
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll,Avril A. B. Robertson,Jae Jin Chae,Sarah C. Higgins,Raúl Muñoz-Planillo,Marco Inserra,Irina Vetter,Lara S. Dungan,Brian G. Monks,Andrea Stutz,Daniel E. Croker,Mark S. Butler,Moritz Haneklaus,Caroline E. Sutton,Gabriel Núñez,Eicke Latz,Daniel L. Kastner,Kingston H. G. Mills,Seth L. Masters,Kate Schroder,Mark E. Cooper,Luke A. J. O'Neill +21 more
TL;DR: MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle–Wells syndrome, and is a potential therapeutic for NLRP3-associated syndromes, and a tool for further study of theNLRP3 inflammasome in human health and disease.
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Methods Used to Evaluate Pain Behaviors in Rodents
TL;DR: Concerns over the clinical translatability of stimulus-evoked nociception in recent years has led to the development and increasing implementation of non-stimulus evoked methods, such as grimace scales, burrowing, weight bearing and gait analysis.
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Conus Venom Peptide Pharmacology
TL;DR: The discovery of new bioactives using proteomic/transcriptomic approaches combined with high-throughput platforms and better defining conopeptide structure-activity relationships using relevant membrane protein crystal structures are expected to grow the already significant impact conopePTides have had as both research probes and leads to new therapies.
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Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy
Hana Starobova,Irina Vetter +1 more
TL;DR: This review focusses on the commonly used antineoplastic substances oxaliplatin, cisPlatin, vincristine, docetaxel, and paclitaxel which interfere with the cancer cell cycle—leading to cell death and tumor degradation—and cause severe acute and chronic peripheral neuropathies.
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Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails
Sébastien Dutertre,Sébastien Dutertre,Ai-Hua Jin,Irina Vetter,Brett Hamilton,Kartik Sunagar,Vincent Lavergne,Valentin Dutertre,Bryan G. Fry,Agostinho Antunes,Deon J. Venter,Deon J. Venter,Paul F. Alewood,Richard J. Lewis +13 more
TL;DR: It is proposed that defensive toxins, originally evolved in ancestral worm-hunting cone snails to protect against cephalopod and fish predation, have been repurposed in predatory venoms to facilitate diversification to fish and mollusk diets.