J
Jennifer R. Deuis
Researcher at University of Queensland
Publications - 68
Citations - 2226
Jennifer R. Deuis is an academic researcher from University of Queensland. The author has contributed to research in topics: Peptide & Medicine. The author has an hindex of 22, co-authored 52 publications receiving 1556 citations. Previous affiliations of Jennifer R. Deuis include St. Joseph's Hospital and Medical Center.
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Journal ArticleDOI
Methods Used to Evaluate Pain Behaviors in Rodents
TL;DR: Concerns over the clinical translatability of stimulus-evoked nociception in recent years has led to the development and increasing implementation of non-stimulus evoked methods, such as grimace scales, burrowing, weight bearing and gait analysis.
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An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways
Jennifer R. Deuis,Katharina Zimmermann,Andrej A. Romanovsky,Lourival D. Possani,Peter J. Cabot,Richard J. Lewis,Irina Vetter +6 more
TL;DR: In this article, the authors established a new intraplantar oxaliplatin mouse model that rapidly developed long-lasting cold allodynia mediated entirely through tetrodotoxin-sensitive Nav pathways.
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Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.
Jennifer R. Deuis,Zoltan Dekan,Joshua S. Wingerd,Jennifer J. Smith,Nehan R. Munasinghe,Rebecca F. Bhola,Wendy L. Imlach,Volker Herzig,David A. Armstrong,K. Johan Rosengren,Frank Bosmans,Stephen G. Waxman,Sulayman D. Dib-Hajj,Pierre Escoubas,Michael S. Minett,MacDonald J. Christie,Glenn F. King,Paul F. Alewood,Richard J. Lewis,John N. Wood,Irina Vetter +20 more
TL;DR: The results suggest that in inflammatory models, acute administration of peripherally restricted NaV1.7 inhibitors can only produce analgesia when administered in combination with an opioid.
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Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target.
TL;DR: Findings highlight the complex pathophysiological mechanisms underpinning burn injury-induced pain and suggest that cholecystokinin-2 receptor antagonists may be useful clinically as adjuvants to decrease opioid requirements and improve analgesic management.
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NaV1.7 as a pain target - From gene to pharmacology.
Irina Vetter,Jennifer R. Deuis,Alexander Mueller,Mathilde R. Israel,Hana Starobova,Alan Zhang,Lachlan D. Rash,Mehdi Mobli +7 more
TL;DR: Complexities surrounding targeting Na(V)1.7 pharmacologically for treatment of pain are discussed and future opportunities for development of effective analgesic Na( V) 1.7 inhibitors are explored.