J
Jean-Christophe Bourdon
Researcher at University of Dundee
Publications - 104
Citations - 7358
Jean-Christophe Bourdon is an academic researcher from University of Dundee. The author has contributed to research in topics: Gene isoform & Gene. The author has an hindex of 42, co-authored 96 publications receiving 6556 citations. Previous affiliations of Jean-Christophe Bourdon include French Alternative Energies and Atomic Energy Commission & Centre national de la recherche scientifique.
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Journal ArticleDOI
p53 isoforms can regulate p53 transcriptional activity
Jean-Christophe Bourdon,Kenneth Fernandes,Fiona Murray-Zmijewski,Geng Liu,Alexandra Diot,Dimitris P. Xirodimas,Mark K. Saville,David P. Lane +7 more
TL;DR: It is established that p53beta can bind differentially to promoters and can enhance p53 target gene expression in a promoter-dependent manner, while Delta133p53 is dominant-negative toward full-length p53, inhibiting p53-mediated apoptosis.
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Mdm2-Mediated NEDD8 Conjugation of p53 Inhibits Its Transcriptional Activity
TL;DR: The role for MDM2 as an E3 ligase is expanded, providing evidence that Mdm2 is a common component of the ubiquitin and NEDD8 conjugation pathway and indicating the diverse mechanisms by which E3ligases can control the function of substrate proteins.
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p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
TL;DR: The changes in the interactions between p53, p63 and p73 isoforms are likely to be fundamental to the understanding in the transition between normal cell cycling and the onset of tumour formation.
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Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
TL;DR: The understanding of the regulation of p53 isoform expression and their biological activities in relation to the cellular context would constitute an important step toward the improvement of the diagnostic, prognostic, and predictive values of p 53 in cancer treatment.
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p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
Kaori Fujita,Abdul M. Mondal,Izumi Horikawa,Giang Nguyen,Giang Nguyen,Kensuke Kumamoto,Jane J. Sohn,Elise D. Bowman,Ewy Mathé,Aaron J. Schetter,Sharon R. Pine,Helen Ji,Borivoj Vojtesek,Jean-Christophe Bourdon,David P. Lane,David P. Lane,Curtis C. Harris +16 more
TL;DR: It is shown that the human p53 isoforms Δ133p53 and p53β function in an endogenous regulatory mechanism for p53-mediated replicative senescence, which was observed in vivo in colon adenomas with senescent phenotypes.