M
Marie P. Khoury
Researcher at University of Dundee
Publications - 10
Citations - 992
Marie P. Khoury is an academic researcher from University of Dundee. The author has contributed to research in topics: Cancer & Gene isoform. The author has an hindex of 9, co-authored 10 publications receiving 866 citations. Previous affiliations of Marie P. Khoury include University of Toulouse & French Institute of Health and Medical Research.
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Journal ArticleDOI
Uncovering the role of p53 splice variants in human malignancy: a clinical perspective
TL;DR: The understanding of the regulation of p53 isoform expression and their biological activities in relation to the cellular context would constitute an important step toward the improvement of the diagnostic, prognostic, and predictive values of p 53 in cancer treatment.
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The Isoforms of the p53 Protein
TL;DR: It is established that the p53 isoforms can regulate cell-fate outcome in response to stress, by modulating p53 transcriptional activity in a promoter and stress-dependent manner and it is determined that the dual gene structure is conserved in Drosophila and in zebrafish p53 genes.
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p53 Isoforms: An Intracellular Microprocessor?
TL;DR: Current knowledge about the biological activities of p53 isoforms are summarized and a molecular mechanism conciliating the current knowledge on p53 and integrating p63 and p73 isoforms in the p53 pathway is proposed.
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p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage
Mustapha Aoubala,F. Murray-Zmijewski,Marie P. Khoury,Marie P. Khoury,Kenneth Fernandes,Sébastien Perrier,H. Bernard,H. Bernard,Anne-Catherine Prats,David P. Lane,Jean-Christophe Bourdon,Jean-Christophe Bourdon +11 more
TL;DR: It is reported here that in response to a low dose of doxorubicin, p53 directly transactivates the human p53 internal promoter, inducing Δ133p53α protein expression, which inhibits p53-dependent apoptosis and G1 arrest without inhibiting p 53-dependent G2 arrest.
Journal ArticleDOI
p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
Jean-Christophe Bourdon,Jean-Christophe Bourdon,Marie P. Khoury,Marie P. Khoury,Marie P. Khoury,Alexandra Diot,Lee Baker,Kenneth Fernandes,Mustapha Aoubala,Philip R. Quinlan,Colin A. Purdie,Lee B. Jordan,Anne-Catherine Prats,Anne-Catherine Prats,Anne-Catherine Prats,David P. Lane,Alastair M. Thompson,Alastair M. Thompson +17 more
TL;DR: The determination of p53γ expression may allow the identification, independently of the ER status, of two subpopulations of mutant p53 breast cancer patients, one expressing p53β with a prognosis as good as the wild-type p53 Breast cancer patients and a second one not expressing p 53γ with a particularly poor prognosis.