Joachim Grötzinger

TL;DR: A fusion protein of sIL-6R and IL-6, linked by a flexible peptide chain, that was expressed to high levels was used to effectively expand human hematopoietic progenitor cells ex vivo in a dose dependent fashion.

TL;DR: It is demonstrated that precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal spheres, containing Ahsg, calcium, and phosphate, which turn progressively more crystalline and insoluble in a time- and temperature-dependent fashion.

TL;DR: Preclinical animal disease models have provided strong evidence that specific blockade of IL-6-regulated signalling pathways represents a promising approach for the therapy of these diseases.

TL;DR: Molecular mechanisms of inter-familiar cytokine cross-talk are reviewed which regulate dynamics and strength of IL-6 signal transduction and focus on IL- 6-type cytokine/cytokine receptor plasticity and cross- talk exemplified by the recently identified composite cytokines IL-30/IL-6R and IL-35, the first inter-Familiar IL-8/IL -12 family member.

TL;DR: It is demonstrated that a recombinant, soluble sushi domain of IL-15R alpha, which bears most of the binding affinity forIL-15, behaves as a potent IL- 15 agonist by enhancing its binding and biological effects through the IL-14R beta/gamma heterodimer, whereas it does not affect IL-13 binding and function of the tripartite IL-16R alpha/beta/gammas membrane receptor.