Bernd Denecke

TL;DR: It is shown that endothelial cell–derived apoptotic bodies are generated during atherosclerosis and convey paracrine alarm signals to recipient vascular cells that trigger the production of CXCL12.

TL;DR: It is demonstrated that precipitation inhibition by Ahsg is caused by the transient formation of soluble, colloidal spheres, containing Ahsg, calcium, and phosphate, which turn progressively more crystalline and insoluble in a time- and temperature-dependent fashion.

TL;DR: This study systematically compared in vitro differentiation of mesenchymal stem cells (MSCs) on a variety of groove/ridge structures to provide further insight into how structuring of tailored biomaterials and implant interfaces do not induce differentiation of MSCs per se, but support their directed differentiation.

TL;DR: Fetuins are serum proteins with diverse functions including the regulation of osteogenesis and inhibition of unwanted mineralization, and the recently identified fetuin-B is a second member of the fetuin family, which belongs to the cystatin superfamily.

TL;DR: This review provides a comprehensive overview about the construction of exosomes, their targeting and their fusion mechanisms to the recipient cells, and the design of artificial exosome with a clearly defined therapeutic active cargo and surface marker ensuring the specific targeting to the recipients cells is proposed as a promising approach.