J
Jonathan P. Whitehead
Researcher at University of Queensland
Publications - 87
Citations - 7249
Jonathan P. Whitehead is an academic researcher from University of Queensland. The author has contributed to research in topics: Adiponectin & Insulin resistance. The author has an hindex of 37, co-authored 87 publications receiving 6892 citations. Previous affiliations of Jonathan P. Whitehead include Mater Health Services & Princess Alexandra Hospital.
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Journal ArticleDOI
Congenital leptin deficiency is associated with severe early-onset obesity in humans
C. T. Montague,I S Farooqi,Jonathan P. Whitehead,Maria A. Soos,Harald Rau,Nicholas J. Wareham,C. P. Sewter,JE Digby,S N Mohammed,J A Hurst,C H Cheetham,A R Earley,Anthony H. Barnett,Johannes B. Prins,Stephen O'Rahilly +14 more
TL;DR: The severe obesity found in two severely obese children who are members of the same highly consanguineous pedigree provides the first genetic evidence that leptin is an important regulator of energy balance in humans.
Journal ArticleDOI
Adiponectin--a key adipokine in the metabolic syndrome.
Jonathan P. Whitehead,Ayanthi A. Richards,Ingrid J. Hickman,Graeme A. Macdonald,Johannes B. Prins +4 more
TL;DR: Given the low levels of adiponectin in subjects with the metabolic syndrome, and the beneficial effect of the adipokine in animal studies, there is exciting potential for adiponECTin replacement therapy in insulin resistance and related disorders.
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Resveratrol Does Not Benefit Patients With Nonalcoholic Fatty Liver Disease
Veronique S. Chachay,Graeme A. Macdonald,Jennifer H. Martin,Jonathan P. Whitehead,Trisha O'Moore-Sullivan,Paul Lee,Michael E. Franklin,Kerenaftali Klein,Paul J. Taylor,Maree Ferguson,Jeff S. Coombes,Gethin P. Thomas,Gary Cowin,Carl M. J. Kirkpatrick,Johannes B. Prins,Ingrid J. Hickman +15 more
TL;DR: Eight weeks administration of resveratrol did not significantly improve any features of NAFLD, compared with placebo, but it increased hepatic stress, based on observed increases in levels of liver enzymes.
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Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.
Sumaira Z. Hasnain,Danielle J. Borg,Brooke E. Harcourt,Hui Tong,Yonghua Sheng,Choa Ping Ng,Indrajit Das,Ran Wang,Alice C.-H. Chen,Thomas Loudovaris,Thomas W.H. Kay,Helen E. Thomas,Jonathan P. Whitehead,Josephine M. Forbes,Johannes B. Prins,Michael A. McGuckin +15 more
TL;DR: Therapeutic manipulation of immune regulators of beta cell stress reverses the hyperglycemia central to diabetes pathology.
Journal ArticleDOI
Adiponectin Multimerization Is Dependent on Conserved Lysines in the Collagenous Domain: Evidence for Regulation of Multimerization by Alterations in Posttranslational Modifications
Ayanthi A. Richards,Tim Stephens,Hayley K. Charlton,Alun Jones,Graeme A. Macdonald,Johannes B. Prins,Jonathan P. Whitehead +6 more
TL;DR: Gl glucose-induced increases in HMW multimer production from human adipose explants correlated with changes in the two-dimensional electrophoresis profile of adiponectin isoforms, suggesting that adiponECTin multimer composition is affected by changes in PTM in response to physiological factors.