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Kim L. Ho
Researcher at University of Alberta
Publications - 19
Citations - 851
Kim L. Ho is an academic researcher from University of Alberta. The author has contributed to research in topics: Heart failure & Ketone bodies. The author has an hindex of 7, co-authored 14 publications receiving 455 citations.
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Journal ArticleDOI
Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors.
Subodh Verma,Sonia Rawat,Kim L. Ho,Cory S. Wagg,Liyan Zhang,Hwee Teoh,John E. Dyck,Golam M. Uddin,Gavin Y. Oudit,Eric Mayoux,Michael Lehrke,Nikolaus Marx,Gary D. Lopaschuk +12 more
TL;DR: In this article, the authors evaluated cardiac energy production and bioenergetics in an experimental model of diabetes treated with the SGLT2 inhibitor empagliflozin.
Journal ArticleDOI
Loss of Metabolic Flexibility in the Failing Heart.
TL;DR: An increasing body of evidence shows that increasing cardiac ATP production and/or modulating cardiac energy substrate preference positively correlates with heart function and can lead to better outcomes.
Journal ArticleDOI
Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.
Kim L. Ho,Liyan Zhang,Cory S. Wagg,Rami Al Batran,Keshav Gopal,Jody Levasseur,Teresa C. Leone,Jason R.B. Dyck,John R. Ussher,Deborah M. Muoio,Daniel P. Kelly,Gary D. Lopaschuk +11 more
TL;DR: Increasing ketone oxidation rates in failing hearts increases overall energy production without compromising glucose or fatty acid metabolism, albeit without increasing cardiac efficiency.
Journal ArticleDOI
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Golam M. Uddin,Liyan Zhang,Saumya Shah,Arata Fukushima,Cory S. Wagg,Keshav Gopal,Rami Al Batran,Simran Pherwani,Kim L. Ho,Jamie Boisvenue,Qutuba G. Karwi,Qutuba G. Karwi,Tariq R. Altamimi,David S. Wishart,Jason R.B. Dyck,John R. Ussher,Gavin Y. Oudit,Gary D. Lopaschuk +17 more
TL;DR: It is concluded that impaired cardiac BCAA catabolism and insulin signaling occur in human heart failure, while enhancing BCAA oxidation can improve cardiac function in the failing mouse heart.
Journal ArticleDOI
FoxO1 Regulates Myocardial Glucose Oxidation Rates via Transcriptional Control of Pyruvate Dehydrogenase Kinase 4 Expression
Keshav Gopal,Bruno Saleme,Rami Al Batran,Hanin Aburasayn,Amina Eshreif,Kim L. Ho,Wayne K. Ma,Malak Almutairi,Farah Eaton,Manoj Gandhi,Edwards A. Park,Edwards A. Park,Gopinath Sutendra,John R. Ussher +13 more
TL;DR: It is demonstrated that pyruvate dehydrogenase kinase 4 is a direct transcriptional target of FoxO1 (but not FoxO3/FoxO4) in the heart, thereby controlling PDH activity and subsequent glucose oxidation rates.