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Qutuba G. Karwi
Researcher at University of Alberta
Publications - 33
Citations - 1092
Qutuba G. Karwi is an academic researcher from University of Alberta. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 13, co-authored 23 publications receiving 490 citations. Previous affiliations of Qutuba G. Karwi include Petra University & University of Diyala.
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Journal ArticleDOI
Loss of Metabolic Flexibility in the Failing Heart.
TL;DR: An increasing body of evidence shows that increasing cardiac ATP production and/or modulating cardiac energy substrate preference positively correlates with heart function and can lead to better outcomes.
Journal ArticleDOI
Cardiac Energy Metabolism in Heart Failure
TL;DR: In this paper, the effects of metabolic changes that occur in heart failure are complex and are dependent not only on the severity and type of heart failure present but also on the co-existence of common comorbidities such as obesity and type 2 diabetes.
Journal ArticleDOI
Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure
Golam M. Uddin,Liyan Zhang,Saumya Shah,Arata Fukushima,Cory S. Wagg,Keshav Gopal,Rami Al Batran,Simran Pherwani,Kim L. Ho,Jamie Boisvenue,Qutuba G. Karwi,Qutuba G. Karwi,Tariq R. Altamimi,David S. Wishart,Jason R.B. Dyck,John R. Ussher,Gavin Y. Oudit,Gary D. Lopaschuk +17 more
TL;DR: It is concluded that impaired cardiac BCAA catabolism and insulin signaling occur in human heart failure, while enhancing BCAA oxidation can improve cardiac function in the failing mouse heart.
Journal ArticleDOI
AP39, a mitochondria‐targeting hydrogen sulfide (H2S) donor, protects against myocardial reperfusion injury independently of salvage kinase signalling
Qutuba G. Karwi,Julia Bornbaum,Kerstin Boengler,Roberta Torregrossa,Matthew Whiteman,Mark E. Wood,Rainer Schulz,Gary F. Baxter +7 more
TL;DR: The potential cardioprotective effect of a mitochondria‐specific H2S donor, AP39, at reperfusion against ischaemia/reperfusion injury is investigated.
Journal ArticleDOI
Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction
Qutuba G. Karwi,Qutuba G. Karwi,Liyan Zhang,Cory S. Wagg,Wang Wang,Manoj Ghandi,Dung Thai,Hai Yan,John R. Ussher,Gavin Y. Oudit,Gary D. Lopaschuk +10 more
TL;DR: mAb A-mediated cardioprotection post-myocardial infarction is associated with improved insulin sensitivity and a selective enhancement of glucose oxidation via, at least in part, enhancing branched chain amino acids catabolism.