K
Kris Chadee
Researcher at University of Calgary
Publications - 112
Citations - 5293
Kris Chadee is an academic researcher from University of Calgary. The author has contributed to research in topics: Entamoeba histolytica & Mucin. The author has an hindex of 36, co-authored 98 publications receiving 4413 citations.
Papers
More filters
Journal ArticleDOI
Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa
Kirk Bergstrom,Vanessa Kissoon-Singh,Deanna L. Gibson,Caixia Ma,Marinieve Montero,Ho Pan Sham,Natasha R. Ryz,Tina Huang,Anna Velcich,B. Brett Finlay,Kris Chadee,Bruce A. Vallance +11 more
TL;DR: Muc2 production is critical for host protection during A/E bacterial infections, by limiting overall pathogen and commensal numbers associated with the colonic mucosal surface and limiting tissue damage and translocation of pathogenic and Commensal bacteria across the epithelium.
Journal ArticleDOI
The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells.
TL;DR: Among the three bacterial groups contained in VSL#3, the Lactobacillus species were the strongest potentiator of mucin secretion in vitro, and this findings contribute to a better understanding of the complex and beneficial interaction between colonic epithelial cells and intestinal bacteria.
Journal ArticleDOI
Roles and regulation of the mucus barrier in the gut.
TL;DR: Insight into how factors modulate the mucus barrier in the gut is necessary in order to develop strategies to combat these disorders.
Journal ArticleDOI
Role of Intestinal Mucins in Innate Host Defense Mechanisms against Pathogens
TL;DR: The putative uncharted aspects of mucin-derived innate host defenses, whose exploration will help drug developers to identify factors that can strengthen mucosal integrity and will facilitate basic science research into curative treatments for gastrointestinal diseases are summarized.
Journal ArticleDOI
Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel
TL;DR: A specific cleavage mechanism used by an enteric pathogen to disrupt the polymeric nature of the mucin gel is identified and suggests a major role for E.h. cysteine proteases in overcoming the protective mucus barrier in the pathogenesis of invasive amoebiasis.