S
Steve Cornick
Researcher at University of Calgary
Publications - 12
Citations - 712
Steve Cornick is an academic researcher from University of Calgary. The author has contributed to research in topics: Entamoeba histolytica & Mucus. The author has an hindex of 11, co-authored 12 publications receiving 517 citations.
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Journal ArticleDOI
Roles and regulation of the mucus barrier in the gut.
TL;DR: Insight into how factors modulate the mucus barrier in the gut is necessary in order to develop strategies to combat these disorders.
Journal ArticleDOI
The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction
TL;DR: Engagement of α5β1 integrin across the parasite-host junction is a key regulatory step that initiates robust inflammatory responses to Eh and is proposed to function with NLRP3 as pathogenicity sensor for invasive Eh infection.
Journal ArticleDOI
High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.
TL;DR: In gastrointestinal inflammation, high MUC2 biosynthesis and goblet cell apoptosis lead to a dysfunctional epithelial barrier, so Enhancing M UC2 folding may help alleviate gobleT cell depletion and maintain mucosal integrity.
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VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis
TL;DR: Changes in intestinal immune state and microbiota composition, as well as increased susceptibility to experimental colitis in mice deficient for VAMP8 are described.
Journal ArticleDOI
Entamoeba histolytica: Host parasite interactions at the colonic epithelium
Steve Cornick,Kris Chadee +1 more
TL;DR: This review summarizes how Eh interacts with the intestinal epithelium and subverts host defense mechanisms in disease pathogenesis and describes how the parasite outsmarted the immune system.