K
Kursad Genc
Researcher at Dokuz Eylül University
Publications - 60
Citations - 3980
Kursad Genc is an academic researcher from Dokuz Eylül University. The author has contributed to research in topics: Erythropoietin & Neuroprotection. The author has an hindex of 28, co-authored 60 publications receiving 3458 citations. Previous affiliations of Kursad Genc include University of Chicago.
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Journal ArticleDOI
Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.
Murat Celik,Necati Gokmen,Serhat Erbayraktar,Mustafa Akhisaroglu,Selman KonakC,Cagnur Ulukus,Sermin Genc,Kursad Genc,Emel Sagiroglu,Anthony Cerami,Michael Brines +10 more
TL;DR: Clinical trials evaluating rHu-EPO's potential to prevent motor neuron apoptosis and the neurological deficits that occur as a consequence of ischemic injury are warranted.
Journal ArticleDOI
The adverse effects of air pollution on the nervous system.
TL;DR: Emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology.
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Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
Burak Ibrahim Arioz,Bora Tastan,Emre Tarakcioglu,Kemal Ugur Tufekci,Melis Olcum,Nevin Ersoy,Alper Bagriyanik,Kursad Genc,Sermin Genc +8 more
TL;DR: Melatonin prevents LPS and Adenosine triphosphate (ATP) induced NLRP3 inflammasome activation in murine microglia in vitro, evidenced by inhibition ofNLRP3 expression, Apoptosis-associated speck-like protein containing a CARD (ASC) speck formation, caspase-1 cleavage and interleukin-1 β (IL-1β) maturation and secretion.
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Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy.
TL;DR: It is demonstrated that the number of circulating CD80(+) lymphocytes is increased significantly during MS exacerbations, but is normal in stable MS, and reduction of CD80-mediated costimulation may be one therapeutic mechanism by which IFN-beta acts in MS.
Journal ArticleDOI
Erythropoietin and the nervous system
TL;DR: The current knowledge on the neurotrophic and neuroprotective properties of Epo, the mechanisms by which Epo produces neuroprotection and the signal transduction systems regulated by Epo in the nervous system are summarized.